Registration Dossier
Registration Dossier
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EC number: 203-441-9 | CAS number: 106-91-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Nitschke
- Year:
- 1 990
- Bibliographic source:
- Nitschke, K. et al., Unpublished report of The Dow Chemical Company (acute inhalation) (1990)
- Title:
- No information
- Author:
- OECD
- Year:
- 1 999
- Bibliographic source:
- OECD SIDS for glycidyl methacrylate, December 1999
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,3-epoxypropyl methacrylate
- EC Number:
- 203-441-9
- EC Name:
- 2,3-epoxypropyl methacrylate
- Cas Number:
- 106-91-2
- Molecular formula:
- C7H10O3
- IUPAC Name:
- oxiran-2-ylmethyl methacrylate
- Test material form:
- other: liquid
- Details on test material:
- 99.8% pure based on gas chromatography
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 105 ppm (610 mg/m3), 269 ppm (1563 mg/m3), 412 ppm (2394 mg/m3).
412 ppm was the highest practically attainable vapour concentration. - No. of animals per sex per dose:
- 5 males and 5 females at each dose level
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 412 ppm
- Exp. duration:
- 4 h
- Mortality:
- None
- Clinical signs:
- other: The highest concentration was the maximum practically attainable concentration and lower concentrations were run due to eye effects observed at higher concentrations. At nominal concentrations of 412 ppm (2,394 mg/m3) and 269 ppm (1,563 mg/m3), weight los
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
