Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Testing was conducted between 30 April 2009 and 11 May 2009.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Date of Signature: 04/03/09 Date of Inspection: 19/08/08
Type of method:
effusion method: vapour pressure balance

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Sponsor's identification : PDE-28
Description : red powder
Batch number : 1RF-8017
Date received : 23 March 2009
Storage conditions : room temperature in the dark

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
0 Pa
Transition / decomposition
Transition / decomposition:
no

Any other information on results incl. tables

Run 1:

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

2.59

2.590E-09

0.003595584

-2.444230615

186

459.15

0.002177937

3.22

3.220E-09

0.004470185

-2.349674507

187

460.15

0.002173204

3.22

3.220E-09

0.004470185

-2.349674507

188

461.15

0.002168492

3.53

3.530E-09

0.004900544

-2.309755673

189

462.15

0.002163800

3.14

3.140E-09

0.004359124

-2.360600731

190

463.15

0.002159128

2.90

2.900E-09

0.004025943

-2.395132381

191

464.15

0.002154476

4.32

4.320E-09

0.005997267

-2.222046632

192

465.15

0.002149844

3.92

3.920E-09

0.005441964

-2.264244312

193

466.15

0.002145232

4.79

4.790E-09

0.006649747

-2.177194865

194

467.15

0.002140640

4.32

4.320E-09

0.005997267

-2.222046632

195

468.15

0.002136067

3.45

3.450E-09

0.004789484

-2.319711284

No statistical analysis is given due to the nature of the plot

Run 2

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

2.83

2.830E-09

0.003928765

-2.405743943

186

459.15

0.002177937

2.12

2.120E-09

0.002943103

-2.531194518

187

460.15

0.002173204

1.49

1.490E-09

0.002068502

-2.684344110

188

461.15

0.002168492

3.45

3.450E-09

0.004789484

-2.319711284

189

462.15

0.002163800

2.51

2.510E-09

0.003484523

-2.457856657

190

463.15

0.002159128

3.77

3.770E-09

0.005233726

-2.281189029

191

464.15

0.002154476

3.30

3.300E-09

0.004581245

-2.339016439

192

465.15

0.002149844

2.83

2.830E-09

0.003928765

-2.405743943

193

466.15

0.002145232

4.16

4.160E-09

0.005775146

-2.238437048

194

467.15

0.002140640

5.34

5.340E-09

0.007413288

-2.129989122

195

468.15

0.002136067

4.55

4.550E-09

0.006316566

-2.199518982

No statistical analysis is given due to the nature of the plot

Run 3

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

1.41

1.410E-09

0.001957441

-2.708311266

186

459.15

0.002177937

2.43

2.430E-09

0.003373463

-2.471924105

187

460.15

0.002173204

2.35

2.350E-09

0.003262402

-2.486462516

188

461.15

0.002168492

2.20

2.200E-09

0.003054164

-2.515107698

189

462.15

0.002163800

3.69

3.690E-09

0.005122665

-2.290504013

190

463.15

0.002159128

1.33

1.330E-09

0.001846381

-2.733678738

191

464.15

0.002154476

3.38

3.380E-09

0.004692306

-2.328613678

192

465.15

0.002149844

3.69

3.690E-09

0.005122665

-2.290504013

193

466.15

0.002145232

3.69

3.690E-09

0.005122665

-2.290504013

194

467.15

0.002140640

3.22

3.220E-09

0.004470185

-2.349674507

195

468.15

0.002136067

3.61

3.610E-09

0.005011605

-2.300023177

No statistical analysis is given due to the nature of the plot

Run 4

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

2.20

2.200E-09

0.003054164

-2.515107698

186

459.15

0.002177937

3.14

3.140E-09

0.004359124

-2.360600731

187

460.15

0.002173204

4.08

4.080E-09

0.005664085

-2.246870216

188

461.15

0.002168492

1.26

1.260E-09

0.001749203

-2.757159834

189

462.15

0.002163800

2.98

2.980E-09

0.004137003

-2.383314115

190

463.15

0.002159128

2.51

2.510E-09

0.003484523

-2.457856657

191

464.15

0.002154476

3.14

3.140E-09

0.004359124

-2.360600731

192

465.15

0.002149844

3.14

3.140E-09

0.004359124

-2.360600731

193

466.15

0.002145232

3.61

3.610E-09

0.005011605

-2.300023177

194

467.15

0.002140640

3.61

3.610E-09

0.005011605

-2.300023177

195

468.15

0.002136067

4.55

4.550E-09

0.006316566

-2.199518982

No statistical analysis is given due to the nature of the plot

Run 5

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapour Pressure (Pa)

Log10Vp

185

458.15

0.002182691

2.20

2.200E-09

0.003054164

-2.515107698

186

459.15

0.002177937

1.65

1.650E-09

0.002290623

-2.640046435

187

460.15

0.002173204

2.51

2.510E-09

0.003484523

-2.457856657

188

461.15

0.002168492

2.20

2.200E-09

0.003054164

-2.515107698

189

462.15

0.002163800

2.83

2.830E-09

0.003928765

-2.405743943

190

463.15

0.002159128

1.57

1.570E-09

0.002179562

-2.661630726

191

464.15

0.002154476

2.43

2.430E-09

0.003373463

-2.471924105

192

465.15

0.002149844

3.06

3.060E-09

0.004248064

-2.371808952

193

466.15

0.002145232

4.40

4.400E-09

0.006108327

-2.214077702

194

467.15

0.002140640

2.75

2.750E-09

0.003817705

-2.418197685

195

468.15

0.002136067

3.38

3.380E-09

0.004692306

-2.328613678

No statistical analysis is given due to the nature of the plot

No statistical analyses were performed because the balance readings were too low and variable for a line of best fit to have any meaning. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapour pressure at 25ºC.

Run 5 was chosen because the sample had been under vacuum for the longest period prior to this run and so degassing would have been the most complete. The reading at 193ºC (466.15 K) was chosen because this is the data point which gives the highest estimated vapour pressure at any given temperature when a slope of –1500 K is imposed upon it.

The value of –1500 K is an in-house value and is the shallowest slope observed whilst determining the vapour pressure on a wide range of samples using the vapour pressure balance method. Extrapolation to 25ºC gave a vapour pressure of 9.392 x 10-5 Pa which has been taken as a maximum for this material.

The test material did not change in appearance under the conditions used in the determination.


Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test material has been determined to be less than 9.4 x 10-5 Pa at 25ºC.
Executive summary:
The vapour pressure was determined using Method A4, and was calulated to be less than 9.4 x 10-5 Pa at 25 deg C.