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EC number: 202-327-6 | CAS number: 94-36-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted in accordance with a recognized scientific procedure for analyzing the acute inhalation toxicity of a test material in experimental animals. However, only males were tested and no gross pathology results were reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- only one sex used (males), few data are provided on exposure conditions.
- Principles of method if other than guideline:
- Federal Hazardous Substances Act, Chapter II, Title 16 CFR
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dibenzoyl peroxide
- EC Number:
- 202-327-6
- EC Name:
- Dibenzoyl peroxide
- Cas Number:
- 94-36-0
- Molecular formula:
- C14H10O4
- IUPAC Name:
- diphenylperoxyanhydride
- Details on test material:
- Purity = 78 percent; white granules (remainder water).
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Spartan albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 232-248 g
- Housing: by groups of 5 animals, in metal cages
- Food and water were available ad libitum pre- and post-exposure
ENVIRONMENTAL CONDITIONS
- Temperature and humidity were controlled quarters throughout the pre-exposure and post-exposure periods
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- A single group of 10 male rats were placed in a sealed 59.1 liter glass chamber and exposed for 4 hours to a dynamic atmosphere of test material.
- Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- Concentrations were calculated
- Duration of exposure:
- 4 h
- Concentrations:
- 24.3 mg/l (the physical properties of the test material prohibited exposure of the test rats to highest atmospheric concentrations).
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (then the rats were sacrified)
- Frequency of observations and weighing: during the expsoure period, the rats were observed continuously for changes in behavior and/or appearance
- Necropsy of rats who died during or after the exposure: yes
- Necropsy of survivors performed: no - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 24.3 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: no mortality
- Mortality:
- No mortality was observed at a single dose of 24.3 mg/L.
- Clinical signs:
- other:
- Body weight:
- Body weight gain was determined to be normal throughout study.
- Gross pathology:
- not performed (none of the animals died during and after the exposure)
- Other findings:
- No more data
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- No mortality occured at a concentration of 24.3 mg/L of dibenzoyl peroxid (no highest concentration could be tested, limitations from the physical properties of the substance).
- Executive summary:
The acute inhalation toxicity of dibenzoyl peroxide was evaluated in a 4-hour, single-exposure study in rats according to a method similar to the OECD Guideline 403 (May 12th1981). A limit test was performed: dibenzoyl peroxide was administered to a single group of ten male rats (Spartan strain) via whole-body vapor exposure at concentrations of 24.3 mg/L during 4 hours.
Mortality, clinical observations for clinical signs and body weight changes were evaluated over a 14-day observation period. Detailed clinical observations were conducted immediately following each exposure at 1 day, 2 days, and 5 days post-exposure.
No mortality occured during the exposure and during the post-exposure period.
During the exposure period, eye squint, dyspnea, salivation, lacrimation, erythema, increased and decreased respiratory rates, and increased and decreased motor activity were observed. After 24 hours post-exposure, all rats appeared normal. Observable signs after 48 hours post-exposure were soft stools. All animals appeared normal from day 5 until the end of the study. A few of the rats showed signs of ocular irritation (corneal opacity, ulceration of corneal surface)
Based on the results of this results, LD50 is expected to be more than 24.3 mg/L in rats, Spartan strain following a whole-body exposure to dust during 4 hours.
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