Formic acid

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, well documented and acceptable for assessment. Case report of severe systemic toxicity following incidental dermal contact.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1995

Materials and methods

Study type:

human medical data

Test material

Test material information

Constituent 1

Reference substance name:

Formic acid

EC Number:

200-579-1

EC Name:

Formic acid

Cas Number:

64-18-6

Molecular formula:

CH2O2

IUPAC Name:

formic acid

Results and discussion

Any other information on results incl. tables

RS-Freetext:
Systemic toxicity developed in a 3-year old girl burned by 90% formic  acid over 35% of her total body surface area. The patient presented with  profound metabolic acidosis and a serum formate level of 400 µg/ml, the  highest reported in the literature for poisoning by any route.

The patient was discharged after intensive medical care on day 71. She  had no significant sequelae of her systemic toxicity.

Applicant's summary and conclusion

Conclusions:

CL-Freetext:
Formic acid was absorbed through the skin and caused severe systemic toxicity. A serum formate level of 400 µg/ml, the highest reported in the literature for poisoning by any route, was seen.