Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-800-4 | CAS number: 88-12-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: non-GLP study from peer-reviewed secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report: 1-vinyl-2-pyrrolidone, CAS: 88-12-0, 2nd Priority List, Volume 39
- Author:
- European Commission
- Year:
- 2 003
- Bibliographic source:
- available at: http://echa.europa.eu/documents/10162/1ebf6d5f-e907-4ca2-a3b4-909fd5f359d1
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- Remarks:
- limited details available
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-vinyl-2-pyrrolidone
- EC Number:
- 201-800-4
- EC Name:
- 1-vinyl-2-pyrrolidone
- Cas Number:
- 88-12-0
- Molecular formula:
- C6H9NO
- IUPAC Name:
- 1-ethenylpyrrolidin-2-one
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Intact skin. No other data.
- Duration of exposure:
- no data
- Doses:
- 200, 375, 800, 1000, or 2000 mg/kg of test substance
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 560 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At ≥375 mg/kg-bw, mortality was seen within 5 days of dosing; at ≥1000 mg/kg-bw, mortality was 100%; no mortality occurred at the low dose of 200 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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