Registration Dossier
Registration Dossier
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EC number: 200-664-3 | CAS number: 67-68-5
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- SOFTWARE
QSAR ECOSAR V 1.1
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- The ECOSAR (ECOlogocal Structure Activity Relationship) Class Program for Microsoft Word
- Author:
- Arkema
- Year:
- 2 022
- Bibliographic source:
- U.S. Envionmental Protection agency, Office of Chemical Safety and Pollution Prevention, July 24, 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The ECOSAR model from US EPA Episuite software: ECOSAR v1.1
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl sulfoxide
- EC Number:
- 200-664-3
- EC Name:
- Dimethyl sulfoxide
- Cas Number:
- 67-68-5
- Molecular formula:
- C2H6OS
- IUPAC Name:
- dimethyl sulfoxide
- Test material form:
- liquid
- Details on test material:
- Chemical registery number : CAS 67-68-5 / EC 200-664-3
Chemical name : dimethyl sulfoxide (DMSO)
Constituent 1
Results and discussion
Effect concentrations
- Dose descriptor:
- EC50
- Effect conc.:
- 3 459.78 mg/L
- Remarks on result:
- ChV (chronic value, QSAR)
- Details on results:
- Calculated value
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculated ChV value from ECOSAR v1.11 is 3459.780 mg/L.
- Executive summary:
A simulation was performed using ECOSAR v1.11. The calculated value supports the non toxicity of the dimethylsulfoxide
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