Registration Dossier

Categories

Categories

Category name:
RE_501_C12-C22 Long Chain Alkyl Methacrylates

Justifications and discussions

Category definition:
Chemical category name: C12-C22 Long Chain Alkyl Methacrylates
Category rationale:
Category rationale
- category applicability domain: set of inclusion and/or exclusion rules
- category justification: Due to trends and substantial similarities observed in environmental toxicity, distribution and fate, mammalian ADME (adsorption, distribution, metabolism and excretion), and toxicology between long chain (C12 – C22) linear and branched alkyl methacrylates, a category approach was used for these compounds.

The category is defined as methacrylate esters of linear and branched C12 to C22 alcohols. The long chain (C12-C22) linear and branched alkyl methacrylates included in this category show structure activity relationship and substantial similarities with respect to environmental toxicity, distribution and fate, and mammalian toxicity.