Registration Dossier
Registration Dossier
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EC number: 200-467-2 | CAS number: 60-29-7
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
0.83, 20 °C (shaken flask)
0.89, 20 °C
1.05 (calculated, KOWWIN v1.67a)
1.19 (calculated, SPARC v4.5)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.05
- at the temperature of:
- 20 °C
Additional information
Perusal of the logPow values measured by Collander (1951), as reported in Sangster (1989), shows reasonable agreement with other workers, giving an indication as to the general reliability of Collander's results and experimental technique. However, some details of the experimental procedure are lacking. The experimental value of 0.89 was preferred by Sangster (1989), but again no details on the experimental conditions were available.
Comparison of the KOWWIN predictions for dimethyl ether and dipropyl ether show very good accuracy, to within 0.03 log units of the experimental values (presumably because they are part of KOWWIN's training set). SPARC predictions are to within 0.13 log units. Given the quality of the predictions for analogous substances, the QSAR values are taken to be more reliable than the available experimental data for diethyl ether. Because KOWWIN has slightly better predictions and documentation, it is selected as the value to be carried forward. There are no regulatory cut-offs within the uncertainty of the prediction to warrant further experimental study.
The available information is considered to be adequate for the purposes of classification and labelling and risk assessment, according to Regulation (EC) No. 1907/2006, Annex XI, 1.2, based on the weight-of-evidence.
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