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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
Triphenyl phosphite
EC Number:
202-908-4
EC Name:
Triphenyl phosphite
Cas Number:
101-02-0
Molecular formula:
C18H15O3P
IUPAC Name:
triphenyl phosphite

In vivo test system

Test animals

Species:
mouse
Strain:
CBA/Ca
Sex:
female
Details on test animals and environmental conditions:
Animals were nulliparous and non-pregnant.

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
0, 2.5, 5, 10%
No. of animals per dose:
4

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Key result
Parameter:
SI
Value:
5.16
Test group / Remarks:
Concentration: 2.5%
Key result
Parameter:
SI
Value:
7.79
Test group / Remarks:
Concentration: 5%
Key result
Parameter:
SI
Value:
7.84
Test group / Remarks:
Concentration: 10%
Key result
Parameter:
EC3
Value:
0.014
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: 0% (Vehicle) - 783.39 2.5% - 4041.29 5% - 6099.18 10% - 6143.04

Any other information on results incl. tables

Conc

dpm/

node

Test / Control Ratio

Result

Vehicle (acetone/olive oil 4:1)

783.39

N/A

N/A

2.5%

4041.29

5.16

Positive

5%

6099.18

7.79

Positive

10%

6143.04

7.84

Positive

EC3= 1.4% (Calculated using log equation method)

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
TPP was sensitising at all dose levels (2.5, 5, and 10%). The EC3 value is 1.4% from this study.
Executive summary:

The EC3 value is 1.4%, indicating that TPP is a sensitiser.