Registration Dossier
Registration Dossier
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EC number: 700-455-1 | CAS number: 380843-75-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 June 2009 - 31 August 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- ; view full study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- EC Number:
- 700-455-1
- Cas Number:
- 380843-75-4
- Molecular formula:
- C26H29Cl2N5O3
- IUPAC Name:
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- Details on test material:
- Equipment
HPLC System: Agilent Series 1200
HPLC Column: Phenomenex Luna 3u C18(2), 100A, 150x4.6mm
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- >= 0.003 - <= 0.005 g/L
- Temp.:
- 20 °C
- pH:
- ca. 7
- Remarks on result:
- other: By HPLC
- Water solubility:
- ca. 0.007 g/L
- Temp.:
- 25 °C
- Remarks on result:
- other: using US EPA fragment-based structure-property software WATERNT v.1.01
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
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