Registration Dossier
Registration Dossier
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EC number: 205-524-5 | CAS number: 142-16-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Dioctyl maleate was positive in two Guinea Pig Magnusson-Kligman maximization tests, and negative in a Buhler test. An unreliable human case report (with one human) and a patch test were positive for skin sensitization reactions with up to 10% dioctyl maleate. Patch testing was conducted with individual ingredients of the moisturizing lotion containing 2, 5, and 10% dioctyl maleate. However, test conducted with 100% undiluted dioctyl maleate resulted in about 15% positive skin reaction in comparison to the control areas of all animals which were normal, therefore, we could not conclude that dioctyl maleate is a well defined skin sensitizer.
Justification for classification or non-classification
According to Regulation (EC) No 1272/2008, dioctyl maleate is non classifiable as skin sensitizer.
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