Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report Date:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The test substance was applied to 3 rabbits and their reactions observed for 14 days.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Benzyl Acetate
- Lot/batch No.: RIFM HRB-03-1184
Specific details on test material used for the study:
- Name of test material (as cited in study report): Benzyl Acetate
- Lot/batch No.: RIFM HRB-03-1184
- Description: Clear colourless liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No information provided

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
No information provided
Duration of exposure:
No information provided
Doses:
5g/kg body weight
No. of animals per sex per dose:
3 animals used
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
No information provided

Results and discussion

Preliminary study:
Not relevant
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 other: g/kg body weight
Based on:
not specified
Mortality:
No deaths observed
Clinical signs:
No abnormal clinical signs observed
Body weight:
No information provided
Gross pathology:
No information provided
Other findings:
No information provided

Any other information on results incl. tables

No information provided

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the results of this study, the LD50 of the test substance was determined to be greater than 5g/kg bodyweight. According to Regulation EC No. 1272/2008, the test substance does not require classification.
Executive summary:

In a study conducted by Moreno (1972), the test substance, Benzyl Acetate, was applied to 3 rabbits at a dose of 5g/kg body weight. The rabbits were observed for 14 days following application. The study resulted in an LD50 determined to be greater than 5g/kg bodyweight. According to Regulation EC No. 1272/2008, the test substance does not require classification.