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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species, other
Type of information:
calculation (if not (Q)SAR)
Remarks:
Estimated by calculation
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
This data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained. This handbook is well recognised and reliable.
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study
Qualifier:
no guideline required
Principles of method if other than guideline:
This data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained.
GLP compliance:
no
Remarks:
Not required
Radiolabelling:
no
Details on sampling:
Not relevant
Vehicle:
no
Details on preparation of test solutions, spiked fish food or sediment:
Not relevant
Test organisms (species):
other: Please see below
Details on test organisms:
Calculations are based on the following species: Fathead minnow, Bluegill sunfish, Rainbow trout and Mosquito fish
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
not specified
Hardness:
Estimation by Calculation
Test temperature:
Estimation by Calculation
pH:
Estimation by Calculation
Dissolved oxygen:
Estimation by Calculation
TOC:
Estimation by Calculation
Salinity:
Estimation by Calculation
Details on test conditions:
Estimation by Calculation
Nominal and measured concentrations:
Estimation by Calculation
Reference substance (positive control):
not required
Remarks:
Estimation by Calculation
Details on estimation of bioconcentration:
BASIS FOR CALCULATION OF BCF
log Kow = 1.96 (Sangster, 1989)
Equation: Log BCF = 0.76 Log Kow - 0.23 (Equation no 5.2 - Handbook of Chemical Estimation Methods)
Applicable range of Kow = 7.9 to 8100000

Equation gives Log BCF = 8
Type:
BCF
Value:
8 dimensionless
Basis:
not specified
Details on kinetic parameters:
Please see Table 1 for full calculation
Metabolites:
Not relevant
Results with reference substance (positive control):
Not relevant
Details on results:
Please see Table 1 for full calculation
Reported statistics:
Please see Table 1 for full calculation

Table 1: results

Molecular Weight

Log K(ow)

Log (l/s)

l/s (l/mol)

S (mol/L)

S (mg/L)

Log BCF calc.

BCF

Bioaccumulation Significant?

S measured mg/L

Vp mmHg at 20°C

VOC defined as vp >0.076 mm Hg

HLC calc Pa m3/mol

HLC Quoted/measured Pa m3/mol

Ex Croner Env

LogKoc calc

Koc calc

Koc quoted/measured

Interpretation of Koc

Log Koc calc

Koc calc

138

1.96

0.99

9.76

1.02E-01

14142

0.90

8

N

2660

0.12

Y

0.8

 

M

1.39

25

250 (Tessenderlo)

M

1.8

57

 

Validity criteria fulfilled:
not applicable
Remarks:
Estimation by calculation
Conclusions:
The log Kow value of Benzyl acetate is 1.96 (Sangster, 1989). The logKow is below the trigger of 3 therefore the substance is not expected to bioaccumulate in living organisms.
Executive summary:

The logKow value of Benzyl acetate was found to be 1.96 (Sangster, 1989). The logKow is below the trigger of 3 therefore the substance is not expected to bioaccumulate in living organisms. According to Column 2 of Annex IX of the REACH regulation, no bioaccumulation study is required if the logKow is below the trigger of 3.

However, data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained.

Using the above logKow figure, a BCF was derived using the Handbook of Chemical Property Estimation Methods.The BCF was found to be 8. According to the guidance on information requirements and chemical safety assessment part B, Benzyl acetate is not considered to be hazardous as the BCF is below 10.

Description of key information

The log Kow value of Benzyl acetate was found to be 1.96 (Sangster, 1989). The log Kow is below the trigger of 3 therefore the substance is not expected to bioaccumulate in living organisms. According to Column 2 of Annex IX of the REACH regulation, no bioaccumulation study is required if the log Kow is below the trigger of 3.

However, data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained.

Using the above log Kow figure, a BCF was derived using the Handbook of Chemical Property Estimation Methods. The BCF was found to be 8. According to the guidance on information requirements and chemical safety assessment part B, Benzyl acetate is not considered to be hazardous as the BCF is below 10.

Key value for chemical safety assessment

BCF (aquatic species):
8 dimensionless

Additional information