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EC number: 204-016-0 | CAS number: 112-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Feb. 1987 - 6 Mar 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to adequate guideline and adequately reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Guideline:
- other: FIFRA - Acute oral - Limit test (40 CFR 798)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Oleonitrile
- EC Number:
- 204-016-0
- EC Name:
- Oleonitrile
- Cas Number:
- 112-91-4
- Molecular formula:
- C18H33N
- IUPAC Name:
- (9Z)-octadec-9-enenitrile
- Reference substance name:
- Oleylnitrile
- IUPAC Name:
- Oleylnitrile
- Details on test material:
- Arneel OD: !00% Oleylnitrile CAS 112-91-4
Lot no.: 1512704
Received: 18 Feb. 1987
Dark yellow liquid.
Stored at room temperature in clear glass jar
No other information included in report
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Murphy Breeding Laboratories, Inc.
- Age at study initiation: young adults
- Weight at study initiation: 154-244 g at start study
- Fasting period before study: overnight
- Housing: Singly in stainless steel wire mesh suspension cages
- Diet (e.g. ad libitum): ad libitum: PURINA LABORATORY CHOM
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: at least 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not indicated
- Humidity (%): not indicated
- Air changes (per hr): not indicated
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 19 Feb 1987 - 6 Mar 1987
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Test material was administered once undiluted at 5 g/kgbw by esophageal intubation.
- Doses:
- undiluted at 5 g/kgbw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Animals were observed for gross signs of systemic toxicity and mortality several times (more often if animals exhibited definite signs of toxicity) during the day of dosing, and at least twice daily for a total of 14 days.
The observation and times of observation were documented. Animals were weighed on the day of dosing and seven days after treatment. At the end of the observation period, the animals were sacrificed by carbon dioxide inhalation, weighed, dipped ten times in isopropanol, and given a gross necropsy. The isopropanol was evaporated and the residue sent to the sponsor. All observations were doewnented, but tissues were not saved. - Statistics:
- not applicacble: Depending on results of study, the matial is placed in one of the classifications for hazard rating potential (40 CFR 156, Proposed):
Category I - Up to and including 50 mg/kg
Category II - Greater than 50 mg/kg thru 500 mg/kg
Category III - Greater than 500 mg/kg thru 5000 mg/kg
Category IV - Greater than 5000 mg/kg.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed during the 14-day observation period
- Clinical signs:
- other: Clinical signs generally observed up to the end of the 14-day period in all animals, consisted of pilo-erection, urine stains, scruffy hair coat, red-brown stains around the nose, coats oily on the dorsal side, alopecia on the back (one female, two males)
- Gross pathology:
- The left kidney of one female appeared slightly hollowed. There were no other gross pathological changes noted in the remaining
animals. - Other findings:
- No organ weights of histopathology was performed. No other findings are reported.
Any other information on results incl. tables
Body weight Data:
Sex | Body weight (gain) in gram | |||
Day 0 | Day 7 | Day 14 | Gain 1-14 | |
M | 231 | 279 | 308 | 77 |
M | 230 | 269 | 295 | 65 |
M | 243 | 286 | 327 | 84 |
M | 244 | 280 | 325 | 81 |
M | 237 | 268 | 298 | 61 |
Mean | 237 | 276 | 311 | 74 |
SD | 7 | 8 | 15 | 10 |
F | 172 | 189 | 210 | 38 |
F | 170 | 214 | 244 | 74 |
F | 162 | 206 | 224 | 62 |
F | 172 | 199 | 213 | 41 |
F | 154 | 186 | 203 | 49 |
Mean | 166 | 199 | 219 | 53 |
SD | 8 | 12 | 16 | 15 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute lethal oral dose to rats was found to be > 5000 mg/kg.
- Executive summary:
Oleylnitrile of technical pure quality was tested for acute oral toxicity at a dose level of 5000 mg/kg to groups of five female and five male rats. The animals were observed up to14 days after dosing for mortality, clinical signs, body weight and post mortem examination.
There were no mortalities observed. Body weight gain was normal during the 14 -day observation period for all groups.
Clinical signs were generally observed up to the end of the 14-day period in all animals, and consisted of pilo-erection, urine stains, scruffy hair coat, redbrown stains around the nose, coats oily on the dorsal side, and areas of alopecia on the back or hind legs.
Terminal autopsy findings were normal except for the left kidney of one female that appeared slightly hollowed.
Conclusion: The acute lethal oral dose to rats was found to be > 5000 mg/kg.
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