Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 628-856-6 | CAS number: 1218787-29-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 Jan - 8 Feb 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and well reported. Some small deviations from guideline study, but study is robust enough for reliable outcome.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 2 M+2F per dose group rather then 5 of same sex.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- C12-18 evennumbered alkyl nitrile
- EC Number:
- 628-856-6
- Cas Number:
- 1218787-29-1
- Molecular formula:
- No molecular formula
- IUPAC Name:
- C12-18 evennumbered alkyl nitrile
- Details on test material:
- Test subsatnce: Nitril KK
Appearance: clear yellow liquid
Subsatnce data sheet included in report:
alkylnitril, technical grade
CAS: 61789-53-5
Specific gravity: 0.82 at 20°C
mp ~0°C
bp ~200-350 °C
flashpoint: > 60 °C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: HC/CFY (Remote Sprague-Dawley)
- Source: Hacking and Churchill Limited, Huntingdon, Cambridgeshire, England.
- Age at study initiation: 4-6 weeks
- Weight at study initiation: 100-137 g
- Fasting period before study: night before
- Housing: in groups by sex in metal cages with wire mesh floors.
- Diet: ad libitum, standard laboratory rodent diet (Scientific Feeds LAD 1 obtained from Special Diet Services Ltd., Witham, Essex, England)
- Water: ad libitum
Analyse cerificate for doet and water are included in report.
- Acclimation period: minimum 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23
- Humidity (%): mean daily level: 45%
- Air changes (per hr): 15/hr
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 22 Jan - 8 Feb 1985
Dates of dosing: 22.1.1985 (25 mg/kg), 23.1.1985 (200 mg/kg), 24.1.1985 (2000 mg/kg), 25.1.1985 (5000 mg/kg)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- except lowest dose: 25% in water
- Details on oral exposure:
- Substance was administered as supplied at a volume not exceeding 6.1ml/kg ((= 5 g/kg; S.G. 0.82) or was prepared as a 25% w/v solution in distilled water and administered at a volume of 0.1 ml/kg.
Administration by syringe and plastic catheter or a glass microlitre syringe and metal cannula.
Dosing started with the lowest dose and when no deaths occurred at this level within 24 hours, the next dose was given to another group of two male and two female rats and so on. - Doses:
- 25, 200, 2000 and 5000 mg/kg
- No. of animals per sex per dose:
- 2 male and 2 female per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: frequent after dosing, subsequent days at least twice per day. Recorded were nature, severity, approximate time of onset and duration of each toxic sign.
- Body weight weer recorded on days 1, 4, 8 and 15.
- Necropsy of survivors performed: yes. Consisted of opening the abdominal and thoracic cavities. Macroscopic appearance of abnormal organs when present was recorded.
- Other examinations performed: no - Statistics:
- Not needed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality at highest dose.
- Mortality:
- No
- Clinical signs:
- other: Yes. Complete recovery by day 4 and 5 (5000 mg/kg group). Signs observed shortly after dosing in all rats: pilo-erection and hunched posture. Additional observations incldued: - Abnormal gait (waddlig): 25 and 2000 mg/kg - Pallor extremities ans salivatio
- Gross pathology:
- Terminal autopsy findings were normal.
Any other information on results incl. tables
Average body weight (two animals per sex per dose)
Day | Dose levels in mg/kg | |||
25 | 200 | 2000 | 5000 | |
Males | ||||
1 | 109 | 113 | 120 | 130 |
4 | 153 | 154 | 165 | 176 |
8 | 198 | 201 | 211 | 222 |
15 | 270 | 277 | 276 | 288 |
Females | ||||
1 | 106 | 107 | 112 | 123 |
4 | 137 | 138 | 152 | 153 |
8 | 170 | 166 | 180 | 183 |
15 | 205 | 201 | 208 | 211 |
No. of rats in group of 2 showing signs
Signs | Dose (mg/kg) | |||||||
25 | 200 | 2000 | 5000 | |||||
M | F | M | F | M | F | M | F | |
Pilo-erection | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
Abnormal body carriage (hunched posture) | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
Abnormal gait (waddling) | 2 | 2 | 0 | 0 | 2 | 2 | 0 | 0 |
Pallor of extremities | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 |
Diarrhoea | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
Increased salivation | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal oral dose to rats was found to be > 5000 mg/kg.
- Executive summary:
Coco nitrile of technical pure quality was tested for acute oral toxicity in dose levels upto 5000 mg/kg to groups of two female and two male rats. The animals were observed up to14 days after dosing for mortality, clinical signs, body weight and post mortem examination. Dose levels applied were 25, 200, 2000 and 5000 mg/kgbw.
There were no mortalities observed. Body weight gain was normal during the 14 -day observation period for all groups.
Clinical signs observed in all animals were pilo-erection and hunched posture, and abnormal gait (waddling) at 25 and 2000 mg./kg, pallor of the extremities and increased salivation at 2000 mg/kg, and diarrhoea at 5000 mg/kg. All signs weer completely cleared by day 4 (25, 200 and 2000 mg/kg) or day 5 (5000 mg/kg).
Terminal autopsy findings were normal.
Conclusion: The acute lethal oral dose to rats was found to be > 5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.