Allyl methacrylate

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1994-07-06 to 1994-09-22

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

92/69/EEC

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

adopted 1984

Deviations:

no

GLP compliance:

yes

Analytical monitoring:

yes

Details on sampling:

no data

Vehicle:

no

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A stock solution (1 g/L) was prepared. The test solutions were prepared by a serial dilution of the stock solution.

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Age at study initiation (mean and range, SD): < 24 h
- Length at study initiation: 0.56 mm

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Post exposure observation period:

no

Hardness:

no data

Test temperature:

20 - 22 °C

pH:

7.95 - 8.09

Dissolved oxygen:

7.7 - 8.1 mg/L

Salinity:

not applicable

Nominal and measured concentrations:

Nominal test concentrations:
0, 1, 2.5, 5, 7.5, 10, 25, 50 mg/L

Measured test concentrations:
0, 1, 2.4, 4.8, 7.2, 10, 24, 47

Details on test conditions:

TEST SYSTEM
- Test vessel: glass beakers (120 mL)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4


TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ultrapure water


EFFECT PARAMETERS MEASURED:
Mobility after 24 and 48 hours.

Reference substance (positive control):

not required

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

< 1 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

< 1 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2.4 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

4.8 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Conclusions:

The 48-h EC50 of Allyl methacrylate to daphnia magna was 2.4 mg/L.

Executive summary:

In an OECD 201 (92/69 EEC) under static conditions the 48-h EC50 of Allyl methacrylate to daphnia magna was 2.4 mg/L based on arithemtric mean measured concentrations.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

EC50 48 h (static): 2.4 mg/L; OECD 202

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

2.4 mg/L

Additional information

The acute toxicity of allyl methacrylate on Daphnia magna was tested in a static test set up according OECD guideline 202. The test was terminated after 48 hours of exposure. Based on mean measured concentrations an EC50 of 2.4 mg/L was determined (Elf Atochem, 1994).