Registration Dossier
Registration Dossier
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EC number: 461-670-1 | CAS number: -
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Study design
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Fisons
- Type: Pump: 600E (Waters), injector: 717plus (Waters)
- Type, material and dimension of analytical (guard) column: Hypersil CN (Interchim) particle size 5 μm, length 250mm, inner diameter 4.6 mm
- Detection system: UV; (2487 Waters, wavelength 210 nm
MOBILE PHASES
- Type: methanol - Milli-Q water
- Experiments with additives carried out on separate columns: no
- pH: 6.40
- Solutes for dissolving test and reference substances: acetamide, methylbenzoate, naphtalene, 1,2,3-trichlorobenzene, phenantrene, DTT
DETERMINATION OF DEAD TIME
- injection of a solution of formamide was performed in duplicate (2040 ng)
DETERMINATION OF RETENTION TIMES injected volume: 20 μl
- Quantity of test substance introduced in the column: 104 ng
- Quantity of reference substances: acetamide 74 ng
methylbenzoate 108 ng
naphtalene 15 ng
1,2,3-trichlorobenzene 76 ng
phenantrene 36 ng
DTT 400 ng
- Intervals of calibration: before and after injections
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': k' = (tr-t0) / t0 (t0: HPLC dead time, tr: HPLC retention timeof the items)
- Determination of the log Koc value: the log k' data of the reference items were plotted against their log Koc values
from batch equilibrum. using this plot, the Koc values determined for the reference
items were within ± 0.5 log units of the values determined by the batch equilibrum
method in the guideline and the log k' value of the test item was then used to
determine its log Koc value. (within 0.25 log units)
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- >= 1 229 - <= 1 231
- Type:
- log Koc
- Value:
- >= 3.08 - <= 3.1
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: formamide 3.32
acetanilide 3.90
methylbenzoate 4.38
naphtalene 5.64
1,2,3-trichlorobenzene 6.35
phenantrene 8.82
DTT 16.86
- Average retention data for test substance: 5.89
Applicant's summary and conclusion
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