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EC number: 236-671-3 | CAS number: 13463-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.003 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 0.4 mg/L
Additional information
The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.
The acute studies on fish indicate that ZPT is toxic to fish. The LC50values range from 0.0026 to 0.4 mg ZPT/L withPimephales promelas(Fathead minnow) being the most sensitive species (seeTable40).
Acute exposure of fish (Pimephalespromelas) to ZPT resulted in an NOEC value of 0.0011 mg ZPT/L.
Further, acute toxicity studies in fish for the major metabolites (seeTable41andTable42) indicate that the most toxic substance is Pyrithione disulphide with a NOEC of 0.03-1.1 mg/L, again to the freshwater species Pimephales promelas (Fathead Minnow), but that this is some 30 times less toxic than the parent compound Zinc Pyrithione. However, Pyrithione disulphide is very short lived in the environment and the most relevant degradant of ZPT is Pyridine sulphonic acid (PSA).
Table35:Acute toxicity of ZPT to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|||||
US EPA- 72-1 |
Freshwater Fathead Minnow Pimephales promelas
|
Mortality
|
Flow-through |
96 hours |
0.0011 |
0.0026 |
>0.0079 |
Key study
NOEC assigned to concentration that allowed at least 90% survival and did not cause sub lethal effects
|
Boeri RL, Magazu JP, Ward TJ (1994) Unpublished study |
US EPA- 72-3 (b) |
Marine Sheepshead Minnow Cyprinodon variegates
|
Mortality
|
Semi-static |
96 hours |
0.20 |
0.40 |
0.59 |
- |
Boeri RL, Magazu JP, Ward TJ (1994) Unpublished study |
US EPA- 72-1 |
Freshwater Rainbow trout Oncorhyncus mykiss
|
Mortality
|
Flow-through |
96 hours |
0.0016 |
0.0032 |
0.0087 |
- |
Boeri RL, Magazu JP, Ward TJ (1994) Unpublished study
|
US EPA -540/9-85-006 |
Freshwater Rainbow trout Oncorhyncus mykiss
|
Mortality
|
Flow-through |
96 hours |
<0.018 |
0.150 |
0.320 |
- |
Croudace CP, Caunter JE, Eales GJ (1996). Unpublished study |
Table36:Acute toxicity ofPyridine-N-oxide-2-sulfonic acidto fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|||||
US EPA- 72-1 |
Freshwater Fathead Minnow Pimephales promelas |
Mortality
|
Flow-through |
96 hours |
48.7 |
58.8 |
- |
Key study |
Ward TJ, Kowalski PL, Boeri RL (1994) Unpublished study |
US EPA- 72-1 |
Freshwater Rainbow trout Oncorhyncus mykiss |
Mortality
|
Flow-through |
96 hours |
73.6 |
92.3 |
- |
- |
Ward TJ, Kowalski PL, Boeri RL (1994) Unpublished study |
US EPA- 72-3 (b) |
Marine Sheepshead Minnow Cyprinodon variegatus |
Mortality
|
Flow-through |
96 hours |
137 |
>137 |
- |
- |
Boeri RL, Kowalski PL, Ward TJ (1994) Unpublished study |
Table37:Acute toxicity of Pyridine sulphonic acid to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|||||
US EPA- 72-1 |
Freshwater Fathead Minnow Pimephales promelas |
Mortality |
Flow-through |
96 hours |
55.2 |
68.5 |
- |
- |
Boeri RL, Kowalski PL, Ward TJ (1994) Unublished study |
US EPA- 72-1 |
Freshwater Rainbow trout Oncorhyncus mykiss |
Mortality |
Flow-through |
96 hours |
46.9 |
57.1 |
- |
- |
Ward TJ, Kowalski PL, Boeri RL (1993) Unpublished study |
US EPA- 72-3 (b) |
Marine Sheepshead Minnow Cyprinodon variegatus |
Mortality |
Flow-through |
96 hours |
127 |
>127 |
- |
- |
Boeri RL, Kowalski PL, Ward TJ (1994) Unpublished study |
Table38:Acute toxicity of 2,2’-(pyridyl-N-oxide) disulphide to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|||||
US EPA- 72-1 |
Freshwater Fathead Minnow Pimephales promelas |
Mortality |
Flow-through |
96 hours |
0.011 |
0.030 |
- |
- |
Ward TJ, Magazu JP, Boeri RL (1995) Unpublished study |
US EPA- 72-1 |
Freshwater Rainbow trout Oncorhyncus mykiss |
Mortality |
Flow-through |
96 hours |
0.018 |
0.054 |
- |
- |
Ward TJ, Magazu JP, Boeri RL (1995) Unpublished study |
US EPA- 72-3 (b) |
Marine Sheepshead Minnow Cyprinodon variegatus |
Mortality |
Flow-through |
96 hours |
<0.52 |
1.1 |
- |
- |
Ward TJ, Magazu JP, Boeri RL (1995) Unpublished study |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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