Octadecan-1-ol, ethoxylated

Repeated dose toxicity: oral

Administrative data

Endpoint:

short-term repeated dose toxicity: oral

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Justification for type of information:

Please refer to the category justification provided in the category object.

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Octadecan-1-ol, ethoxylated

EC Number:

500-017-8

EC Name:

Octadecan-1-ol, ethoxylated

Cas Number:

9005-00-9

Molecular formula:

not applicable, UVCB

IUPAC Name:

2-octadecoxyethanol

Results and discussion

Effect levels

Key result

Dose descriptor:

NOAEL

Effect level:

1 000 mg/kg bw/day (actual dose received)

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other: No toxicologically relevant effects observed

Target system / organ toxicity

Key result

Critical effects observed:

no

Any other information on results incl. tables

For a detailed assessment of the repeated dose toxicity of the Alcohol Ethoxylates (AE) category, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Conclusions:

Applying read-across based on grouping of substances (category approach), no toxicologically relevant effects after short-term repeated dose administration and a NOAEL for systemic toxicity ≥ 1000 mg/kg bw/day are predicted for the registered substance.

Executive summary:

The available data on repeated dose toxicity in the 'linear' subgroup of the Alcohol Ethoxylates (AE) category indicates no toxicologically relevant effects for the registered substance. As explained in the category justification, the differences in molecular structure and composition between the registered substance and the members of the AE category are unlikely to lead to differences with respect to short-term repeated dose toxicity.