Trimethyl borate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1955

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data to permit interpretation of study results

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1955

Report date:

1955

Reference 2

Reference Type:

publication

Title:

Unnamed

Year:

1962

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Range finding study.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trimethyl borate

EC Number:

204-468-9

EC Name:

Trimethyl borate

Cas Number:

121-43-7

Molecular formula:

C3H9BO3

IUPAC Name:

trimethyl borate

Details on test material:

- Name of test material (as cited in study report): Methyl borate
- Molecular formula (if other than submission substance): C3H9BO3
- Molecular weight (if other than submission substance): 103.9
- Physical state: Liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: In-House
- Age at study initiation: 4 to 5 weeks
- Weight at study initiation: 90 to 120 grams

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

Single oral dose toxicity estimation by gastric intubation.

Doses:

Not available.

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

Single dose oral toxicity was estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4 to 5 weeks of age and weighing 90 to 120 grams. Animals were maintained on Rockland rat diet since weaning. The dosages were arranged in a logarithmic series differingby a factor of two.

Statistics:

Based upon mortalities during a 14 -day observation period, the most probable LD50 value and its fiducial range were estimated by the method of Thompson using the Tables of Weil.

Results and discussion

Preliminary study:

No data available.

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

5 551 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Data mentioned in the report is 6.1 ml/kg; which is converted to mg/kg (5551 mg/Kg).

Mortality:

No data available.

Clinical signs:

other: No data available.

Gross pathology:

No data available.

Other findings:

None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 value considered is 5551 mg/kg body weight and its fiducial range is 4550 - 7280 mg/kg body weight.

Executive summary:

Single dose oral toxicity was estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4 to 5 weeks of age and weighing 90 to 120 grams. Animals were maintained on Rockland rat diet since weaning.

The dosages were arranged in a logarithmic series differing by a factor of two. Based upon mortalities during a 14 -day observation period, the LD50 value and its fiducial range were estimated by the method of Thompson using the Tables of Weil.

Based upon mortalities during a 14 -day observation period, the LD50 value considered is 5551 mg/kg body weight and its fiducial range is 4550 - 7280 mg/kg body weight.