Registration Dossier
Registration Dossier
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EC number: 203-577-9 | CAS number: 108-39-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- accumulation of 14C
- GLP compliance:
- no
- Radiolabelling:
- yes
- Vehicle:
- no
- Test organisms (species):
- Leuciscus idus melanotus
- Route of exposure:
- aqueous
- Test type:
- static
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 3 d
- Hardness:
- 100 mg CaO/l
- Test temperature:
- 20-25 °C
- pH:
- 7
- Details on test conditions:
- 5 fish (2-4 g) exposed in closed system
- Nominal and measured concentrations:
- 0.05 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- Hexachlorobenzene and several others
- Details on estimation of bioconcentration:
- concentrations were determined by following radioactivity in fish and water
- Type:
- BCF
- Value:
- >= 17 - <= 20
- Basis:
- whole body w.w.
- Calculation basis:
- other: after 3 d
- Remarks on result:
- other: Conc.in environment / dose:0.05 mg/L
- Validity criteria fulfilled:
- not specified
- Executive summary:
Bioconcentration factors (BCF) in fish (Leuciscus idus melanotus) were determined with 14C-labelled m-cresol. The fish were exposed to a 0.05 mg/l solution of the tests compound. After the test period of 3 days radioactivity was measured in water medium and fish. BCF values of 20 were obtained.
Reference
Determination of radioactivity includes possible metabolized and/or incorporated intermediates
Description of key information
The experimental determined bioconcentration factor (BCF) of m-cresol in fish (Leuciscus idus melanotus) is 20.
Key value for chemical safety assessment
- BCF (aquatic species):
- 20 dimensionless
Additional information
The bioconcentration factor (BCF) in fish (Leuciscus idus melanotus) was determined with 14C-labelled m-cresol. The fish were exposed to a 0.05 mg/l solution of the tests compound. After the test period of 3 days radioactivity was measured in water medium and fish. A BCF value of 20 were obtained.
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