Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer-reviewed database.

Data source

Reference
Reference Type:
secondary source
Title:
Atochem, Hydrolysis studies on dimethylaminoethyl methacrylate, SA 006/94
Author:
Atochem
Year:
1994
Bibliographic source:
cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
In vitro studies on the hydrolysis of the TS in simulated saliva, simulated intestinal fluid and simulated gastric fluid.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
2-dimethylaminoethyl methacrylate
EC Number:
220-688-8
EC Name:
2-dimethylaminoethyl methacrylate
Cas Number:
2867-47-2
IUPAC Name:
2-(dimethylamino)ethyl methacrylate
Details on test material:
No details.

Administration / exposure

Details on study design:
The TS was incubated in simulated saliva, simulated intestinal fluid or simulated gastric fluid for 4 hours at 37°C.

Results and discussion

Metabolite characterisation studies

Details on metabolites:
The substance was rapidly hydrolysed to methacrylic acid (CAS 79-41-4) and N,N,-dimethylaminoethanol (CAS 108-01-0) when incubated with simulated saliva or simulated intestinal fluid in vitro. 90% degradation was observed in simulated saliva after 4 hours at 37°C, 86% degradation after incubation with simulated intestinal fluid for 4 hours at 37°C. Degradation was below 8% after incubation with simulated gastric fluid for 4 hours at 37°C.

Applicant's summary and conclusion

Conclusions:
The TS is rapidly hydrolysed to methacrylic acid (CAS 79-41-4) and N,N,-dimethylaminoethanol (CAS 108-01-0) when incubated in vitro with simulated saliva or simulated intestinal fluid, but not with simulated gastric fluid.