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Diss Factsheets
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EC number: 219-460-0 | CAS number: 2439-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer-reviewed database.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Atochem, Hydrolysis studies on dimethylaminoethyl methacrylate, SA 006/94
- Author:
- Atochem
- Year:
- 1 994
- Bibliographic source:
- cited in: OECD SIDS, 2-Dimethylaminoethylmethacrylate, CAS No: 2867-47-2, 07/2003
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- In vitro studies on the hydrolysis of the TS in simulated saliva, simulated intestinal fluid and simulated gastric fluid.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-dimethylaminoethyl methacrylate
- EC Number:
- 220-688-8
- EC Name:
- 2-dimethylaminoethyl methacrylate
- Cas Number:
- 2867-47-2
- IUPAC Name:
- 2-(dimethylamino)ethyl methacrylate
- Details on test material:
- No details.
Constituent 1
Administration / exposure
- Details on study design:
- The TS was incubated in simulated saliva, simulated intestinal fluid or simulated gastric fluid for 4 hours at 37°C.
Results and discussion
Metabolite characterisation studies
- Details on metabolites:
- The substance was rapidly hydrolysed to methacrylic acid (CAS 79-41-4) and N,N,-dimethylaminoethanol (CAS 108-01-0) when incubated with simulated saliva or simulated intestinal fluid in vitro. 90% degradation was observed in simulated saliva after 4 hours at 37°C, 86% degradation after incubation with simulated intestinal fluid for 4 hours at 37°C. Degradation was below 8% after incubation with simulated gastric fluid for 4 hours at 37°C.
Applicant's summary and conclusion
- Conclusions:
- The TS is rapidly hydrolysed to methacrylic acid (CAS 79-41-4) and N,N,-dimethylaminoethanol (CAS 108-01-0) when incubated in vitro with simulated saliva or simulated intestinal fluid, but not with simulated gastric fluid.
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