Registration Dossier
Registration Dossier
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EC number: 215-114-8 | CAS number: 1303-00-0
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented analytical results, data generated under the National Health and Nutrition Examination Survey
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Type of study / information:
- data on background urine levels of arsenic and its compunds
- Endpoint addressed:
- other: urine background level
- Principles of method if other than guideline:
- analytical investigation
- GLP compliance:
- yes
- Remarks:
- data generation under government control
Test material
- Reference substance name:
- not applicable
- IUPAC Name:
- not applicable
Constituent 1
Method
- Ethical approval:
- not applicable
Results and discussion
- Results:
- Well documented analytical results were generated under the National Health and Nutrition Examination Survey. 2005 to 2006 the background levels of Arsenic Total, Arsenic(V) acid, Arsenbetaine, Arsencholine, Arsenous (III) acid, Dimethylarsinic acid, Monomethylarsonic acid and Trimethylarsine acid were determined in human urine.
The geometric mean of the creatinine corrected total Arsenic content was: 9.15 µg/g of creatinine, maximum levels were found with non-hispanic blacks, here the upper limit of the 95th percentile confidence interval was 120 µg/g of creatinine.
Applicant's summary and conclusion
- Conclusions:
- 2005 to 2006 the background levels of Arsenic Total, Arsenic(V) acid, Arsenbetaine, Arsencholine, Arsenous (III) acid, Dimethylarsinic acid, Monomethylarsonic acid and Trimethylarsine acid were determined in human urine.
Total Arsenic (creatinine corrected) geometric mean: 9.15 µg/g of creatinine,
maximum levels: 95th percentile confidence interval of non-hispanic blacks: 120 µg/g of creatinine. - Executive summary:
Well documented analytical results, data generated under the National Health and Nutrition Examination Survey. In the years 2005 to 2006 the background urine levels of Arsenic Total, Arsenic(V) acid, Arsenbetaine, Arsencholine, Arsenous (III) acid, Dimethylarsinic acid, Monomethylarsonic acid and Trimethylarsine acid were determined. The geometric mean of the creatinine corrected total Arsenic content was: 9.15 µg/g of creatinine, maximum levels were found with non-hispanic blacks, here the upper limit of the 95th percentile confidence interval was 120 µg/g of creatinine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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