Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Toxicity to terrestrial organisms is discussed.

Additional information

Three higher tier tests are available to assess the toxicity of the substance to terrestrial organisms. The results of these tests are as follows:

OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)

Test soil concentrations of up to 1000 mg/kg resulted in no adverse effects on the seedling emergence and early growth of four of the six species tested (A. sativa, Z. mays, B. napus, G. max).

The NOEC and LOEC for Lactuca sativa (lettuce) were 125 and 250 mg/kg, respectively, based on seedling height.

The NOEC and LOEC for Lycopersicon esculentum (tomato) were 63 and 125 mg/kg, respectively, based on seedling height and dry weight.

OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)

The EC50 value for inhibition of nitrate formation after 28 days was greater than 2500 mg Naugard 445/kg dry soil, the highest concentration tested. Naugard 445 did not have an adverse effect on nitrogen transformation in soil.

OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))

There was no treatment-related mortality of adult earthworms exposed to 4-(1-methyl-1-phenylethyl)-N-[4-(1-methyl-1-phenylethyl)phenyl]aniline at 62.5, 125, 250, 500, and 1000 mg/kg dry soil for 28 days. Based on body weight and survival data of adult earthworms, the no observed effect concentration (NOEC) was determined to be 1000 mg/kg dry soil, the highest concentration tested. There were no reductions of 50% or greater for the numbers of juveniles produced in the treatment groups in comparison to the negative control group, therefore the EC50 for reproduction was greater than 1000 mg/kg dry soil, the highest concentration tested. The NOEC was 62.5 mg/kg dry soil and the LOEC was 125 mg/kg dry soil, based on the numbers of juveniles produced.

 

On the basis of these results it is considered that the test substance does not pose a hazard to terrestrial organisms. No further testing is required to refine risk.

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