Registration Dossier
Registration Dossier
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EC number: 218-760-9 | CAS number: 2226-96-2
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not available
Data source
Reference
- Reference Type:
- publication
- Title:
- Neurophysiological consequences of nitroxide antioxidants
- Author:
- Hahn, S.M., Lepinski, D.L., DeLuca A.M., Mitchell J.B., Pellmar, T.C.
- Year:
- 1 995
- Bibliographic source:
- Can. J. Physiol. Pharmacol. 73, 399-403
Materials and methods
Test material
- Reference substance name:
- 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl
- EC Number:
- 218-760-9
- EC Name:
- 4-hydroxy-2,2,6,6-tetramethylpiperidinoxyl
- Cas Number:
- 2226-96-2
- Molecular formula:
- C9H18NO2•
- IUPAC Name:
- 1-λ1-Oxidanyl-2,2,6,6-tetramethylpiperidin-4-ol
Constituent 1
Results and discussion
Any other information on results incl. tables
4-Hydroxy-TEMPO showed a smaller effect than TEMPO or Tempamine. 1 mM caused a small but significant enhancement of E/S coupling (relationship between PSP and population spike) and synaptic efficacy, at 5 Mmol a greater potentiation of E/S coupling was observed, but the synaptic potential was not altered. The effects were reversible. At the high concentration additionally in 3 of 5 slices a secondary population spike was developed by the somatic field potential, suggesting some hyperexcitability.
Applicant's summary and conclusion
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