Registration Dossier
Registration Dossier
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EC number: 203-978-9 | CAS number: 112-50-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In a reliable and GLP guideline study, the substance showed no evidence of mutagenicity in a bacterial reverse mutation (Ames) assay in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and Escherichia coli strain WP2uvra, with or without metabolic activation.
In a guideline and GLP in vitro chromosome abberation study using human blood lymphocytes, the substance did not induce chromosomal aberrations in human lymphocytes with our without metabolic activation.
In a guideline and GLP HPRT mammalian cell gene mutation assay using Chinese Hamster lung fibroblasts, the substance was unable to induce gene mutations and therefore considered negative in the assay.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
From the available data on the substance, there is no indication of the substance having genotoxic or mutagenic properties, therefore classification is not warranted.
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