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EC number: 203-978-9
CAS number: 112-50-5
In a reliable and GLP guideline study, the substance showed no evidence
of mutagenicity in a bacterial reverse mutation (Ames) assay in
Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 and
Escherichia coli strain WP2uvra, with or without metabolic activation.
In a guideline and GLP in vitro chromosome abberation study using human
blood lymphocytes, the substance did not induce chromosomal aberrations
in human lymphocytes with our without metabolic activation.
In a guideline and GLP HPRT mammalian cell gene mutation assay using
Chinese Hamster lung fibroblasts, the substance was unable to induce
gene mutations and therefore considered negative in the assay.
From the available data on the substance, there is no indication of the
substance having genotoxic or mutagenic properties, therefore
classification is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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