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EC number: 203-978-9
CAS number: 112-50-5
Based on observations from other members of this category, it can be
concluded that the data from TEGME is a good conservative surrogate to
predict the properties of this substance and that it will have low
repeat dose toxicity by all routes of exposure. NOAELs can be predicted
from TEGME after taking into account molecular weight differences.
Further data from sub-acute studies with the substance is being
generated to bring more confidence to this extrapolation.
Repeat toxicity studies are available for a number of substances with
the category by both the dermal and oral routes. (Inhalation
is not considered relevant due to the very low vapour pressure of TEGEE). Some
studies are of higher quality than others since they are more modernFor
the oral route, classification is only required if significant toxic
effects are seen at a dose of 100mg/kg or lower and 200mg/kg for the
dermal route. From the available data from substances
within the category applied to TEGEE, it can be concluded with some
confidence that TEGEE is not likely to meet these criteria and therefore
classification is not required.
The necessity to apply EUH066 for the skin effects seen in the dermal
repeat dose studies with some category members should be considered.
However, since the effects produced by the substances themselves are
not considered sufficient to warrant applying this phrase, it is not
considered appropriate to apply it to TEGEE.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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