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Short-term toxicity to fish

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Description of key information

The substance is with high probability acutely not harmful to fish.

Key value for chemical safety assessment

Additional information

In absence of the experimental data on the short-term toxicity of dipropylamine (CAS 142-84-7) towards fish, the read-across approach was performed to the structurally similar substance diethylamine (CAS 109-89-7). Under supervision of the Japanese Ministry of the Environment an acute fish test according to OECD 203 was conducted under GLP and published in 2000. The test species was Oryzias latipes. The fish were exposed for 96 hours under semi-static conditions to nominal test concentrations of 9.5 to 100 mg/L diethylamine. The test concentrations were analytically verified. The test solutions without pH-adjustment showed initial pH values between 9.1 and 10.6. The acceptable pH range for fish given in the OECD TG 203 (6.0 to 8.5) was only kept in the control, while the test solutions showed initial pH values above 8.5. Therefore, the highest test concentration (100 mg/L) was also tested with pH-adjusted test solutions. A 96 -h LC50 was determined for non-neutralised samples to be 26.7 mg/L (95% CL: 19.7 - 34.8 mg/L, nominal). In the neutralised highest test concentration of 100 mg/L no fish died during the 96 -h of exposure (96 -h LC50 > 100 mg/L, for neutralised test solutions, NITE, 2000, report no.: NMMP/E99/4070).

In conclusion, dipropylamine is with high probability acutely not harmful to fish.

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