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EC number: 905-588-0
CAS number: -
Graphical data showed that all 3 isomers
appeared rapidly in blood and the brain but there were notable
differences in time-course:
- concentrations of o-xylene in both tissues
peaked after 2 hr, remained steady for 3 hr and then declined steadily
- blood m-xylene was maximal 30 min after
administration, remained steady for 11 hr then decreased. Concentrations
in brain paralleled those in the blood but with two peaks at 30 min and
- concentrations of p-xylene in blood and
brain peaked after 30 min then decreased sharply at 1 hr followed by a
more steady decline.
The maximal concentration in blood and brain
differed significantly between the isomers, and was always greatest for
brain concentrations of o-, m- and p-xylene were determined in young
adult male Sprague-Dawley rats following oral gavage administration of
8.47 mmol/kg of each isomer. Levels of p-xylene
in blood and brain (Cmax, AUC) were approx. double, and tissue
half-lives slightly shorter, compared to those found for o- and
m-xylene. Levels of p-xylene in brain (Cmax, AUC) were around 2 to
3-fold greater than those for blood. The results indicate slight
toxicokinetic differences for the three xylene isomers in the rat
following acute oral exposure.
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