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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Investigations on the disposition of oral doses of some water insoluble pigments.
Author:
El Darer, S.M., Tillery, KF., and Hill, D.L.
Year:
1984
Bibliographic source:
Bull. Environ. Contam. Toxicol. 32, 171-174.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study resultsThe absorption of CI Pigment Red 3 (purity, 94.7 %) was studied in male Fischer 344 rats, seven to eight weeks of age, given the compound once at 11.8 mg/kg bw suspended in corn oil by gavage. Gut contents, faeces and various tissues were extracted 1, 4, 24 and 48 h after dosing and the amount of parent compound present was determined. None was found in blood, liver or kidneys, and it was concluded that the compound is not absorbed from the intestinal tract. Recovery after 48 h was 72.4% of the dose, suggesting that the compound may be partly degraded by intestinal bacteria. (The Working Group noted that absorption of cleavage products or metabolites was not analysed.)