Decanal

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference Type:

publication

Title:

Food Flavourings and Compounds of Related Structure I. Acute Oral Toxicity

Author:

Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG

Year:

1964

Bibliographic source:

Food and Cosmetics Toxicology (2) pp327-343

Report date:

1964

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Groups of rats fed test material and observed for 14 d.

GLP compliance:

no

Remarks:

Study predates GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Decanal

EC Number:

203-957-4

EC Name:

Decanal

Cas Number:

112-31-2

Molecular formula:

C10H20O

IUPAC Name:

decanal

Specific details on test material used for the study:

- Name of test material (as cited in study report): Aldehyde C-10 decyl (decanal)
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: approx. 18 hr
- Housing: In cages
- Diet: Ad libitum (except fasting period)
- Water: Ad libitum
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Route of administration:

oral: feed

Vehicle:

unchanged (no vehicle)

Doses:

No data

No. of animals per sex per dose:

5 male, 5 female per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs

Statistics:

LD₅₀ values were computed by the method of Litchfield & Wilcoxon (1949).

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 33 320 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Highest dose administered

Mortality:

No

Clinical signs:

other: Excitation, diarrhoea, wet fur on stomach and posterior

Gross pathology:

No data

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance was assessed for acute oral toxicity using rats in a standard acute toxicity method. The acute oral LD₅₀ of the test substance to rats was >33320 mg/kg bw (the highest dose administered).