Registration Dossier
Registration Dossier
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EC number: 205-999-9 | CAS number: 280-57-9
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
Air Products, 2000, Rep. no. 269303, GLP, OECD 203, Cyprinus carpio, analytically verified test concentrations, 96h LC50 > 100 mg/l (without pH adjustment)
Based on this result, 1,4-Diazabicyclo[2.2.2]octane is with high probability acutely not harmful to fish.
Long-term toxicity to fish
Study waived
Short-term toxicity to aquatic invertebrates
Air Product, 2000, Rep. no. 269314, GLP, OECD 202, Daphnia magna, analytically verified test concentrations, 48h EC50 > 100 mg/l (nominal).
Based on this result, 1,4-Diazabicyclo[2.2.2]octane is with high probability acutely not harmful to aquatic invertebrates.
Long-term toxicity to aquatic invertebrates
BASF SE, 2022, QSAR Toolbox v4.5, Trend analysis, Daphnia magna, substance within the applicability domain, 21d EC10 = 12.3 mg/L.
Based on this result long-term effects on aquatic invertebrates are not expected.
Toxicity to aquatic algae and cyanobacteria
Air Products, 2000, Rep. no. 269325, GLP, OECD 201, Raphidocelis subcapitata, analytically verified test concentrations, 72h ErC50 = 180 mg/l, 72h ErC10 = 79 mg/L.
Based on these results, 1,4-Diazabicyclo[2.2.2]octane is considered as acutely and chronically not harmful to algae.
Toxicity to microorganisms
BASF AG, 1987, 9/0932/87, DIN 38412 part 8, Bringmann-Kuehn, Pseudomonas putida, 17h EC10 = 210.9 mg/L, EC50 = 355.6 mg/L (nominal concentrations)
Based on these results, the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
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