Registration Dossier
Registration Dossier
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EC number: 219-154-7 | CAS number: 2374-14-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No reliable toxicity to aquatic algae data are available for 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane (CAS 2374-14-3).
Testing is not required for the following reasons:
- It is technically not feasible to conduct an aquatic study due to the very low water solubility of the substance (1.3E-06 mg/l) and very high log Kow (9). These values indicate that maintaining stable aqueous test solutions will be extremely difficult. Furthermore, once dissolved, the substance will have the tendency to adsorb onto the glassware under experimental conditions and onto dissolved organic matter in the natural environment.
- Above a log Kow of 6.0 short-term toxicity effects are not expected to occur, because the very limited aqueous solubility prevents toxic concentrations being achieved in exposure media.
- The physicochemical properties and very high value of Koc (6) means that if the substance could enter a wastewater treatment plant in influent waste waters, it would partition mainly to sludge (a small proportion may be volatilised), with a negligible amount passing to water. The result is that exposure of freshwater or marine aquatic compartments is negligible.
- The substance is not manufactured or used as such in the EU and is registered in accordance with the REACH Regulation (Article 6) in order to support import of polymers. Residual unbound monomer in polymer is very low and the substance is of extremely low water solubility, such that unintentional release to the aquatic environment from end use of the polymers is negligible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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