Registration Dossier

Administrative data

Endpoint:
other distribution data
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
not applicable (QSAR)
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
QSAR estimate by an internationally recognized QSAR, within its applicability domain, with correct recognition of the chemical family (hydrazines) and of the compound structure, and based on several experimental data (boiling point, melting point, vapour pressure) which were correctly re-estimated by this QSAR.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR
Title:
EPI Suite Results For CAS 000060-34-4
Author:
Anonymous
Year:
2010
Bibliographic source:
US EPA's Office of Pollution Prevention and Toxics + Syracuse Research Corporation, Estimation Programs Interface (EPI) Suite, v4.00

Materials and methods

Principles of method if other than guideline:
QSAR estimation by KOAWIN v1.10, based on following:
- identification data: SMILES= N(N)C, CAS= 000060-34-4 (software recognizes structure, name and ECOSAR Class= hydrazines)
- experimental input: boiling point, melting point, vapour pressure: values as in IUCLID
- the estimation method used the HENRYWIN v3.20 estimate of Henry's law constant
GLP compliance:
no
Remarks:
QSAR
Type of study:
volatility
Media:
other: octanol-air

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Log Octanol-Air Partition Coefficient (25 deg C): Log Koa = 4.839

Applicant's summary and conclusion

Executive summary:

The Octanol-Air Partition Coefficient estimated by QSAR by KOAWIN v1.10 inside EPIsuite v4.00, is Log Koa = 4.839. The substance partitions more to lipid phase than to air (due to low volatility).

The relevance of the estimate is confirmed by the coherence of three other estimates with available experimental data.