Registration Dossier
Registration Dossier
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EC number: 202-297-4 | CAS number: 94-04-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a GLP or O.E.C.D. Testing Guideline study with few details on experimental dosing and results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Vinyl 2-ethylhexanoate
- EC Number:
- 202-297-4
- EC Name:
- Vinyl 2-ethylhexanoate
- Cas Number:
- 94-04-2
- Molecular formula:
- C10H18O2
- IUPAC Name:
- ethenyl 2-ethylhexanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 16.0, 11.3, 8.0, 5.7, 4.0 and 2.0 ml/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Adult male and female Sprague-Dawley rats were used in this experiment. Rats were dosed with undiluted vinyl 2-ethylhexanoate at (2.0, 4.0, 5.7, 8.0, 11.3, 16.0 ml/kg) by intraesophageal intubation. Food and water were freely available throughout a 14 day observation period.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5.47 mL/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 9.54 mL/kg bw
- Mortality:
- Males: 5/5 at 16.0 ml/kg and 5/5 at 11.3 ml/kg
Females: 2/2 at 16.0 ml/kg and 5/5 at 8.0 ml/kg, 2/5 at 5.7 ml/kg - Clinical signs:
- other: Sluggishness, unstaidy gait, prostration, red crust on perinasal fur, brown wet stain on periurogenital fur.
- Gross pathology:
- Lung mottled red and dark red, dark red kidneys ans trace to large amount of blood in urine at high dose levels in males, 16.0 and 11.3 ml/kg. The effects were seen at lower doses, down to 5.7 ml/kg, in females.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Males: LD50 = 9.54 ml/kg; Females: LD50 = 5.47 ml/kg; No significant lesions observed from microscopic evaluation.
- Executive summary:
Males: LD50 = 9.54 ml/kg; Females: LD50 = 5.47 ml/kg; No significant lesions observed from microscopic evaluation. Vinyl 2 -ethylhexanoate is of low acute toxicity to laboratory rats by the oral routes of exposure.
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