Registration Dossier
Registration Dossier
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EC number: 248-258-5 | CAS number: 27138-31-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Two studies conducted according to international guidelines and in compliance with GLP, are available and valid. The activated sludge respiration inhibition test demonstrated a NOEC ≥ 100 mg/L, the highest concentration tested. The assay on growth of the bacteria Pseudomonas putida demonstrated a NOEC ≥ 10 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
An activated sludge respiration inhibition test was conducted to determine the effect on sewage micro-organisms of the test material DPGDB (HLS 1998, VCL235/970385). The study was conducted in accordance with EC, OECD, and US EPA test guidelines, and in compliance with GLP. DPGDB had no significant inhibitory effect on the respiration rate of activated sludge at any of the concentrations employed in the tests. The NOEC was determined to be ≥ 100 mg/L, the highest concentration tested.
A second study that supports this result was performed to assess the effect of DPGDB on the growth of the bacteria Pseudomonas putida (Safepharm 1998, SPL 1104/001). The method followed that described in the German Water Hazard Classification Scheme Bewertung Wassergefahrdender Stoffe LTWS Nr 10 and ISO 10712, and was conducted to GLP. Exposure of Pseudomonas putida to DPGDB gave EC10 and EC50 values of greater than 10 mg/L . The "no-observed effect level" (NOEC) was >= 10 mg/L.
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