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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Title:
OECD QSAR Toolbox
Year:
2017
Bibliographic source:
http://www.qsartoolbox.org
Report Date:
2017

Materials and methods

Test guideline
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
Protein binding alerts for skin sensitisation by OASIS (www.qsartoolbox.org)
GLP compliance:
no
Type of study:
other: QSAR
Justification for non-LLNA method:
Skin sensitisation is predicted by a validated QSAR model.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Lot/batch No.: 65662468E0
- Name of test material (as cited in study report): DMEE
- Physical state: clear colorless liquid
- Analytical purity: 98.66%
- Expiration date of the lot/batch: 21 March 2016
- Stability under test conditions: stable
- Storage condition of test material: room temperature in the dark
Specific details on test material used for the study:
SMILES: CN(C)CCOCCO

Results and discussion

In vitro / in chemico

Results
Key result
Parameter:
other: negative
Remarks on result:
other: QSAR predicted value

Any other information on results incl. tables

OECD toolbox predicted that 2 -(2 -(dimethylamino)-ethoxy)ethanol CAS 1704 -62 -7 is not skin sensitising.

Applicant's summary and conclusion

Interpretation of results:
other: not skin sensitising