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EC number: 266-582-5
CAS number: 67124-09-8
The available experimental acute toxicity
data for 1-(tert-dodecylthio)propan-2-ol (CAS 67124-09-8) indicate the
need to classify the substance according to Regulation (EC) No.
1272/2008. The short-term values for fish and daphnids (LL50/EL50) are
found far below or around 1 mg/L (Fish: LL50(96h): 0.75 mg/L WAF,
Sewell, 2004 and LL50(96h): 0.42 mg/L WAF, Sewell, 2004; Daphnia magna:
EL50(48h): 0.58 mg/L WAF, Goodband and Mullee, 2011 and EL50(48h): 1.3
mg/L WAF, Sewell, 2004). Furthermore, the substance was found to be not
readily biodegradable by attaining only 5.9 % degradation after 28 days
(Kung, 1998). The partition coefficient was determined experimentally,
resulting in a logPow of 4.72 to 6.51 at 20 °C (Walker, 2011). Taking
this result into account, the predicted Bioconcentration factor (BCF)
range of the substance can be reported as 25.52 - 387 (EPIWIN software
BCFBAF v3.01 by US-EPA). The warranty for a classification and labelling
of the substance cannot be refuted by the experimentally obtained
long-term NOEC/NOELR for daphnids during the conducted 21 -day
reproduction test, since it also far below 1 mg/L (0.32 mg/L WAF,
Wetton, 2003). Water Accomodated Fractions (WAFs) are prepared in the
experiments since the substance was found to be only slightly water
soluble (4.84 mg/L at 20 °C, Woolley and Mullee, 2003). This procedure
is in accordance to the corresponding test guidelines.
Taking into account the described substance
properties, 1-(tert-dodecylthio)propan-2-ol has to be classified as
"Aquatic Chronic 1" with Hazard statement H410 (Very toxic to aquatic
life with long lasting effects) and labelled with hazard pictogram GHS09
(environment) and Precautionary statements P273 (Avoid release to the
environment), P391 (Collect spillage) and P501 (Dispose of
contents/container in accordance with
available acute toxicity data to fish and daphnids leads to the
classification and labelling of the test substance according to
Regulation (EC) No 1272/2008 of the European Parliament and of the
Council. The classification is "Aquatic Chronic 1" with Hazard statement
410 (H410; Very toxic to aquatic life with long lasting effects) and
Precautionary statements P273 (Avoid release to the environment), P391
(Collect spillage) and P501 (Dispose of contents/container in accordance
with local/regional/national/international regulations). The
corresponding label is pictogram GHS 09 (environment).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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