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EC number: 266-582-5
CAS number: 67124-09-8
Bioaccumulation: aquatic / sediment
The bioconcentration factor (BCF) of the
test substance was determined by three different QSAR model tools, which
are scientifically accepted calculation methods and can therefore be
assigned with reliability 2 (reliable with restrictions). No GLP
criteria are applicable for the usage of these tools, but the
predictions can be used for the chemical safety assessment.
regression-based estimate (traditional method) BCFBAF v3.01
a Bioconcentration Factor (BCF) of 105.5 L/kg wet-wt was calculated for
the test substance. Using the less relevant Arnot-Gobas method, which is
based on mechanistic first principles, an aquatic BCF of 1.77E+4 L/kg
wet-wt is the result.
CAESAR QSAR model version 126.96.36.199 predicted a BCF of 143 L/kg body
weight. This value is also predicted by the VEGA BCF model, which is
based on the same principles as CAESAR.
However, based on weight of evidence
bioaccumulation is expected to be below the criterion of concern.
on terrestrial bioaccumulation are not considered to be required for the
substance. In accordance with REACH legislation the test does not need
to be conducted if direct and indirect exposure to the terrestrial
compartment is unlikely. In
addition, the results of the CSR for this substance and the PEC/PNEC
ratios for the local and regional terrestrial compartment indicate no
REACH Chapter R.7B guidance states that if the PEC/PNEC ratio is below
1, then no risk for the compartment is indicated and there is no need to
perform further tests. Furthermore,
this substance does not meet the B or vB criterion and it is not
considered to be a PBT.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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