Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-774-7 | CAS number: 99-63-8
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Dueva LA et al.
- Year:
- 1 989
- Bibliographic source:
- Gig. Tr. Prof. Zabol., (11):50-52 (CA112:71843u)
Materials and methods
Test material
- Reference substance name:
- Isophthaloyl dichloride
- EC Number:
- 202-774-7
- EC Name:
- Isophthaloyl dichloride
- Cas Number:
- 99-63-8
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,3-dicarbonyl dichloride
Constituent 1
Test animals
- Species:
- guinea pig
Administration / exposure
- Route of administration:
- other: epi- or intracutaneous administration
Results and discussion
Results of examinations
- Details on results:
- The test substance induced allergic responses in guinea pigs after epi- or intracutaneous administration. The number of T- and B- lymphocytes of blood usually decreased and increased, respectively. Serum concentrations of albumins and globulins decreased and increased (or had an increasing tendency), respectively.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
