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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: recent test according validated method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
(pyridin-3-yl)methanol hydrofluoride
EC Number:
700-352-1
Cas Number:
62756-44-9
Molecular formula:
C6H8FNO
IUPAC Name:
(pyridin-3-yl)methanol hydrofluoride

In vivo test system

Test animals

Species:
mouse
Strain:
CBA
Sex:
female

Study design: in vivo (LLNA)

Vehicle:
dimethylformamide
Concentration:
25, 50 and 100%
No. of animals per dose:
4

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: Concentration 25 % --> SI = 2.31 Concentration 50 % --> SI = 4.16 Concentration 100 % --> SI = 2.95
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: Concentration 25 % --> DPM = 7913 Concentration 50 % --> DPM = 14182 Concentration 100 % --> DPM = 10084

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
The substance was found to be a sensitiser under the described conditions