Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
behavioural effects
Adequacy of study:
other information

Data source

Reference
Title:
No information
Author:
1) Mullin LS and Krivanek ND (1982) Neurotoxicology, 3,|126-137|2) Kobayashi et al. (1983/1987) Arch Env Hlth, 38, 93-98 /|42, 140-143

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,1-trichloroethane
EC Number:
200-756-3
EC Name:
1,1,1-trichloroethane
Cas Number:
71-55-6
Molecular formula:
C2H3Cl3
IUPAC Name:
1,1,1-trichloroethane
Details on test material:
TS-Freetext:
1) In inhalation studies effects of 1,1,1-TCE on behavior
were observed. Rats exposed to 3780 ppm (20400 mg/m3) or
8480 ppm (45800 mg/m3) for 4 hours lost coordination
(ataxia) and the righting reflex, respectively
(EC50-values). In this study tremors and death were
observedat 12000 ppm (64800 mg/m3) within one hour of
exposure.

2) The inhalation of 0.9 vol% 1,1,1-TCE (9000 ppm, 48600
mg/m3) led to rapid and shallow breathing in dogs. Higher
levels (1.3 vol%) increased the heart rate and 2.8 vol%
decreased the heart rate. Inhalation of 21600 mg/m3 or
43200mg/m3 of 1,1,1-TCE for a few minutes decreased blood
pressure in dogs.

Results and discussion

Applicant's summary and conclusion