Registration Dossier
Registration Dossier
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EC number: 204-070-5 | CAS number: 115-19-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04.05.1988 - 18.05.1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD)
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report - 2-Methylbut-3-yn-ol
- Author:
- BASF AG
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methylbut-3-yn-2-ol
- EC Number:
- 204-070-5
- EC Name:
- 2-methylbut-3-yn-2-ol
- Cas Number:
- 115-19-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 2-methylbut-3-yn-2-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Methylbutin-3-ol-2
- Product No.: 064 522
- Date of bottling: Nov, 1987
- Physical state: liquid, colorless
- Analytical purity: 99.6%
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr . K . Thomae GmbH, 7950 Biberach
- Age at study initiation: ca. 8 - 9 weeks
- Weight at study initiation: male 259 +/- 6.4 g (average), female 185 +/- 6.5 g (average)
- Identification: colormark on tail
- Housing: 5 per cage, Type D III, Firma Becker
- Diet (e.g. ad libitum): ad libitum, KLIBA Labordiät Ratte/Maus, 24-343-4 10 mm Pellet, Klingentalmühle AG, CH-4303 Kaiseraugst
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: steel cage placed in Inhalation chamber made of glass and steel
- Exposure chamber volume: ca. 200l
- Method of holding animals in test chamber: single housing
- Source and rate of air: 3000 l/h, central air conditioning system
- System of generating particulates/aerosols: dosing-pump (DESAGA) and glass-vapourizer attached to air-conditioning system
- Temperature, humidity, pressure in air chamber: 20 - 24 °C, 30 - 70% humidity
TEST ATMOSPHERE
- Brief description of analytical method used: Two beakers connected to a fritted glass beaker filled with the solvent 2-propanol.
- Samples taken from breathing zone: yes, once per hour sample, analyzed by gas chromatography with a GC HP 5840A (Hewlett Packard) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by gas chromatography and substance weight loss during exposure
- Duration of exposure:
- 4 h
- Concentrations:
- 21.3 mg/l
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to begin of study, after 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, mortality - Statistics:
- statistic was calculated acc. binominal model
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 21.3 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- no deaths occured
- Clinical signs:
- other: - During exposition: accelerated and intermittent respiration, narcotic-like condition, lateral position, anemic pallor - until day 8: Abdominal or lateral position, narcotic-like condition, accelerated to intermittent respiration, reduced general state,
- Body weight:
- Body weight gain was delayed in the first week compared to historical control, but equals in the second week.
- average weight prior to begin of study: male 259 g, femal 185 g
- average weight after 7 days: 275 g, 198 g
- average weight after 14 days: 315 g, 208 g - Gross pathology:
- no findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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