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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

From the available data, it can be concluded that the chemical benzidine-2,2'-disulphonic acid is unlikely to exhibit irritating effect on the skin but is slightly irritating to the eyes of rabbit within the concentrations mentioned in the study.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other: modelling database
Principles of method if other than guideline:
Skin irritation (Severe vs mild).Multicase model.
GLP compliance:
no
Species:
other: no data
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
no data
Remarks on result:
other: Severe skin irritation: Negative
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Benzidine-2,2’-disulphonic acid was estimated to be non irritating to skin as per the prediction of the Danish EPA model.
Executive summary:

Benzidine-2,2’-disulphonic acid was estimated to be non irritating to skin as per the prediction of the Danish EPA model.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24H
Basis:
mean
Reversibility:
not specified
Remarks on result:
other: mild irritating
Interpretation of results:
other: mild irritating
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The substance Benzidine-2,2’-disulphonic acid was found to be mild irritating to the eyes of rabbit at dose concentration of 500mg/24 hrs.
Executive summary:

The substance Benzidine-2,2’-disulphonic acid was found to be mild irritating to the eyes of rabbit at dose concentration of 500mg/24 hrs.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Based upon the available data, benzidine-2,2'-disulphonic acid is classified as non-irritating to the skin but slighlty irritating to the eyes of rabbit.

Justification for selection of skin irritation / corrosion endpoint:

Reliable with restriction

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

Based upon the available data, benzidine-2,2'-disulphonic acid is classified as non-irritating to the skin but slighlty irritating to the eyes of rabbit.