Benzidine-2,2'-disulphonic acid

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: Weight of evidence

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

other: Weight of evidence

Title:

Toxicokinetics

Author:

Sustainability Support Services (Europe) AB

Year:

2012

Bibliographic source:

Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier

Materials and methods

Objective of study:

toxicokinetics

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzidine-2,2'-disulphonic acid

EC Number:

204-200-0

EC Name:

Benzidine-2,2'-disulphonic acid

Cas Number:

117-61-3

Molecular formula:

C12H12N2O6S2

IUPAC Name:

4,4'-diamino-[1,1'-biphenyl]-2,2'-disulfonic acid

Test material form:

solid: crystalline

Details on test material:

- Name of test material: Benzidine-2,2’-disulphonic acid
- Molecular formula: C12H12N2O6S2
- Molecular weight: 344.369

Radiolabelling:

not specified

Test animals

Species:

other: unspecified

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

other: estimation

Vehicle:

unchanged (no vehicle)

Control animals:

not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:

The absorption capacity of benzidine-2,2'-disulphonic acid through inhalation route is low (given the extremely low vapour pressure). Absorption through the oral route is also likely to be low given the use of this chemical which is used for the preparation of other chemicals. Thus, dermal route is the most likely route of absorption. However, absorption through the dermal route is expected to be low given the particle size of the chemical which varies from 75 to 150 micrometer in size

Details on distribution in tissues:

In case, the chemical, benzidine-2,2'-disulphonic acid, is absorbed (though in small quantity) it shall not be easily distributed to various parts of the body through blood since the solubility of this chemical in water is moderate. It could be distributed in the lipids within the living system (given its higher solubility in organic solvents). However, since the bio-concentration factor (BCF) of the chemical is very low (ranging from 1.12 to 3.2), it will not be accumulated in the body

Details on excretion:

Further to this distribution after the absorption process, the excretion process through urine would be faster as the molecular weight of the substance, benzidine-2,2'-disulphonic acid, is > 300 and this is normally a favorable value for excretion via the urine route. Some amount of the absorbed chemical can also be excreted through the bile and feaces as the bio-accumulation potential of this chemical is low.

Metabolite characterisation studies

Metabolites identified:

no

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): low bioaccumulation potential based on study results
The substance, benzidine-2,2'-disulphonic acid, is expected to have low bioaccumulation potential based on estimation results supported by the facts of physicochemical parameters and bio-accumulation potential of the substance.

Executive summary:

The substance, benzidine-2,2'-disulphonic acid, is expected to have low bioaccumulation potential based on estimation results supported by the facts of physicochemical parameters and bio-accumulation potential of the substance.