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EC number: 203-581-0 | CAS number: 108-42-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of carbamate herbicides in the rat. I. Metabo1ism of M-chloroani1ine as a constituent of chlorpropham and barban.
- Author:
- Boehme, C. and W. Grunow.
- Year:
- 1 969
- Bibliographic source:
- Food Cosmet. Toxicol. 7 (2): 125-133.
Materials and methods
- Objective of study:
- absorption
- excretion
- metabolism
- Principles of method if other than guideline:
- Data is from Food Cosmet. Toxicol.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):NA
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Erdnussol
- Details on exposure:
- An in-vivo study was conducted in which single 10, 60 or 150 mg/kg doses of 3-chloroaniline in Erdnussol (vehicle) were administered by gavage to male albino rats.
- Duration and frequency of treatment / exposure:
- 24 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10, 60 or 150 mg/kg single doses
- No. of animals per sex per dose / concentration:
- Details not available
- Control animals:
- no
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- 3-Chloroaniline appears to be readily absorbed orally by rats.
- Type:
- metabolism
- Results:
- Hydroxylation of the benzene ring was the primary metabolic alteration, as 2-amino-4-chlorophenol and 4-amino-2-chlorophenol and their glucuronic or sulphuric acid conjugates accounted for -16-25% and 39-50% of the administered doses, respectively.
- Type:
- excretion
- Results:
- substantial portions of single oral doses of 3-ch1oroaniline are excreted in the urine as metabolites within 24 hours. Approximately, 75% of a 10 mg/kg oral dose and 56% of a 150 mg/kg oral dose were excreted in the urine as metabolites or unchanged compd
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 3-Chloroaniline appears to be readily absorbed orally by rats.
- Details on excretion:
- Substantial portions of single oral doses of 3-ch1oroaniline are excreted in the urine as metabolites within 24 hours. Approximately, 75% of a 10 mg/kg oral dose and 56% of a 150 mg/kg oral dose were excreted in the urine as metabolites or unchanged compound within 24 hours
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 2-amino-4-chlorophenol and 4-amino-2-chlorophenol and their glucuronic or sulphuric acid conjugates.
Metabolism: Hydroxylation of the benzene ring was the primary metabolic alteration, as 2-amino-4-chlorophenol and 4-amino-2-chlorophenol and their glucuronic or sulphuric acid conjugates accounted for -16-25% and 39-50% of the administered doses, respectively.
Unchanged 3-chloroaniline accounted for 0.6-1.2% of the administered doses.
Partial acetylation of the amino groups in the phenolic compounds also occurred but was not quantified.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
From the data available on absorption, metabolism and excretion of 3-Chloroaniline in the present study, since the chemical was metabolized as well as rapidly excreted out of the living system in substantial proportions (depending upon the dose administered), it is concluded that 3-Chloroaniline shall have no bio-accumulation potential. - Executive summary:
From the data available on absorption, metabolism and excretion of 3-Chloroaniline in the present study, since the chemical was metabolized as well as rapidly excreted out of the living system in substantial proportions (depending upon the dose administered), it is concluded that 3-Chloroaniline shall have no bio-accumulation potential.
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