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EC number: 203-581-0 | CAS number: 108-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of carbamate herbicides in the rat. I. Metabo1ism of M-chloroani1ine as a constituent of chlorpropham and barban.
- Author:
- Boehme, C. and W. Grunow.
- Year:
- 1 969
- Bibliographic source:
- Food Cosmet. Toxicol. 7 (2): 125-133.
Materials and methods
- Objective of study:
- absorption
- excretion
- metabolism
- Principles of method if other than guideline:
- Data is from Food Cosmet. Toxicol.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report):3-chloroaniline
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):NA
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Erdnussol
- Details on exposure:
- An in-vivo study was conducted in which single 10, 60 or 150 mg/kg doses of 3-chloroaniline in Erdnussol (vehicle) were administered by gavage to male albino rats.
- Duration and frequency of treatment / exposure:
- 24 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10, 60 or 150 mg/kg single doses
- No. of animals per sex per dose / concentration:
- Details not available
- Control animals:
- no
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- 3-Chloroaniline appears to be readily absorbed orally by rats.
- Type:
- metabolism
- Results:
- Hydroxylation of the benzene ring was the primary metabolic alteration, as 2-amino-4-chlorophenol and 4-amino-2-chlorophenol and their glucuronic or sulphuric acid conjugates accounted for -16-25% and 39-50% of the administered doses, respectively.
- Type:
- excretion
- Results:
- substantial portions of single oral doses of 3-ch1oroaniline are excreted in the urine as metabolites within 24 hours. Approximately, 75% of a 10 mg/kg oral dose and 56% of a 150 mg/kg oral dose were excreted in the urine as metabolites or unchanged compd
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 3-Chloroaniline appears to be readily absorbed orally by rats.
- Details on excretion:
- Substantial portions of single oral doses of 3-ch1oroaniline are excreted in the urine as metabolites within 24 hours. Approximately, 75% of a 10 mg/kg oral dose and 56% of a 150 mg/kg oral dose were excreted in the urine as metabolites or unchanged compound within 24 hours
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 2-amino-4-chlorophenol and 4-amino-2-chlorophenol and their glucuronic or sulphuric acid conjugates.
Metabolism: Hydroxylation of the benzene ring was the primary metabolic alteration, as 2-amino-4-chlorophenol and 4-amino-2-chlorophenol and their glucuronic or sulphuric acid conjugates accounted for -16-25% and 39-50% of the administered doses, respectively.
Unchanged 3-chloroaniline accounted for 0.6-1.2% of the administered doses.
Partial acetylation of the amino groups in the phenolic compounds also occurred but was not quantified.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
From the data available on absorption, metabolism and excretion of 3-Chloroaniline in the present study, since the chemical was metabolized as well as rapidly excreted out of the living system in substantial proportions (depending upon the dose administered), it is concluded that 3-Chloroaniline shall have no bio-accumulation potential. - Executive summary:
From the data available on absorption, metabolism and excretion of 3-Chloroaniline in the present study, since the chemical was metabolized as well as rapidly excreted out of the living system in substantial proportions (depending upon the dose administered), it is concluded that 3-Chloroaniline shall have no bio-accumulation potential.
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