Registration Dossier
Registration Dossier
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EC number: 700-962-8 | CAS number: 93924-10-8
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The weight of evidence from the available toxicological information on higher olefins shows that the members of this category have a low hazard potential with regard to human health, with dermal irritation the only effect recorded for some materials. As there are no quantifiable toxicological effects for these substances, DNELs have not been derived.
Acute toxicity
The higher olefins included in this category were not acutely toxic when administered via oral, dermal, or inhalation routes in several animal studies. Hence, these substances do not meet the classification and labelling criteria for acute oral, dermal, or inhalation toxicity according to CLP Regulation 1272/2008. Therefore short-term DNELs will not be derived for these endpoints. In contrast, regulatory classification and labelling for aspiration toxicity relies on the measured or calculated kinematic viscosity of a substance at 40°C rather than results from toxicological studies with animals, with substances where the kinematic viscosity is less than 20.5 mm2/second requiring classified (Category 1 - H304: May be fatal if swallowed and enters airway). All higher olefins included in this category which exist as liquids at 40°C are therefore classified as aspiration hazards because their respective kinematic viscosities are below the discriminating threshold established in the CLP Regulation.
Repeated dose toxicity / toxicity to reproduction
Information on the potential of higher olefin substances included in this category to cause systemic toxicity and toxicity to reproduction is available from a number of studies as indicated in the table below:
Name |
CAS |
Carbon Number |
Study design |
Study type |
Reference |
Hex-1-ene |
592-41-6 |
6 |
OECD 407 |
28-d |
Dotti et al., 1994 |
Hex-1-ene |
592-41-6 |
6 |
OECD 421 |
Repro/dev screen |
Daniel et al., 1995 |
Hex-1-ene |
592-41-6 |
6 |
OECD 413 |
90-d |
Bennick et al., 1984 |
Hex-1-ene |
592-41-6 |
6 |
OECD 408 |
90-d |
Dotti et al., 1994 |
Alkenes, C6 |
68526-52-3 |
6 |
OECD 422 |
RDT and Repro/dev screen |
Thorsrud, 2003 |
1-Tetradecene |
1120-36-1 |
14 |
OECD 422 |
RDT and Repro/dev screen |
Daniel, 1995 |
Alkenes C16-18 |
none |
16-18 |
OECD 424 |
Neurotox |
Clubb, 2000 |
Octadecene |
27070-58-2 |
18 |
OECD 421 |
Repro/dev screen |
Thorsrud, 2003 |
Alkenes C20-24 |
68914-55-6 |
20-24 |
OECD 407 |
28-d |
Dunster, 2008 |
Alkenes C20-24 |
68914-55-6 |
20-24 |
OECD 408 |
90-d |
Brooker, 1999 |
The results from these tests showed no adverse substance-related effects after treatment via oral or inhalation exposure. Hence, these substances do not meet the classification and labelling criteria for repeated toxicity or toxicity to reproduction according to CLP Regulation 1272/2008. Therefore long-term DNELs will not be derived for these endpoints.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The weight of evidence from the available toxicological information on higher olefins shows that the members of this category have a low hazard potential with regard to human health, with dermal irritation the only effect recorded for some materials. As there are no quantifiable toxicological effects for these substances, DNELs have not been derived.
Acute toxicity
The higher olefins included in this category were not acutely toxic when administered via oral, dermal, or inhalation routes in several animal studies. Hence, these substances do not meet the classification and labelling criteria for acute oral, dermal, or inhalation toxicity according to CLP Regulation 1272/2008. Therefore short-term DNELs will not be derived for these endpoints. In contrast, regulatory classification and labelling for aspiration toxicity relies on the measured or calculated kinematic viscosity of a substance at 40°C rather than results from toxicological studies with animals, with substances where the kinematic viscosity is less than 20.5 mm2/second requiring classified (Category 1 - H304: May be fatal if swallowed and enters airway). All higher olefins included in this category which exist as liquids at 40°C are therefore classified as aspiration hazards because their respective kinematic viscosities are below the discriminating threshold established in the CLP Regulation.
Repeated dose toxicity / toxicity to reproduction
Information on the potential of higher olefin substances included in this category to cause systemic toxicity and toxicity to reproduction is available from a number of studies as indicated in the table below:
Name |
CAS |
Carbon Number |
Study design |
Study type |
Reference |
Hex-1-ene |
592-41-6 |
6 |
OECD 407 |
28-d |
Dotti et al., 1994 |
Hex-1-ene |
592-41-6 |
6 |
OECD 421 |
Repro/dev screen |
Daniel et al., 1995 |
Hex-1-ene |
592-41-6 |
6 |
OECD 413 |
90-d |
Bennick et al., 1984 |
Hex-1-ene |
592-41-6 |
6 |
OECD 408 |
90-d |
Dotti et al., 1994 |
Alkenes, C6 |
68526-52-3 |
6 |
OECD 422 |
RDT and Repro/dev screen |
Thorsrud, 2003 |
1-Tetradecene |
1120-36-1 |
14 |
OECD 422 |
RDT and Repro/dev screen |
Daniel, 1995 |
Alkenes C16-18 |
none |
16-18 |
OECD 424 |
Neurotox |
Clubb, 2000 |
Octadecene |
27070-58-2 |
18 |
OECD 421 |
Repro/dev screen |
Thorsrud, 2003 |
Alkenes C20-24 |
68914-55-6 |
20-24 |
OECD 407 |
28-d |
Dunster, 2008 |
Alkenes C20-24 |
68914-55-6 |
20-24 |
OECD 408 |
90-d |
Brooker, 1999 |
The results from these tests showed no adverse substance-related effects after treatment via oral or inhalation exposure. Hence, these substances do not meet the classification and labelling criteria for repeated toxicity or toxicity to reproduction according to CLP Regulation 1272/2008. Therefore long-term DNELs will not be derived for these endpoints.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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