5-chloro-2-(4-chlorophenoxy)phenol;[DCPP]

Toxicity to microorganisms

Administrative data

Endpoint:

activated sludge respiration inhibition testing

Type of information:

other: Transformation product of Diclosan

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only short abstract of guideline study, details missing, e.g. information on activated sludge

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4640-07-7

Cas Number:

4640-07-7

IUPAC Name:

4640-07-7

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

- Name of test material (as cited in study report): FAT 80221/A
- Physical state: white powder
- Analytical purity: > 99%
- Lot/batch No.: C-950/Thomas Maier
- Expiration date of the lot/batch: expiration date: 30 Sept 2010
- Storage condition of test material: at room temperature

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 1.06 and 10.02 mg weighed, added to respective test vessels, then filled up to 100 mL with tapwater after adding 3.2mL synthetic sewage feed and 40 mL sludge

Test organisms

Test organisms (species):

other: activated sludge

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

3 h

Test conditions

pH:

8.0 to 8.2

Nominal and measured concentrations:

Nominal: blank, 10 and 100 mg/L

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

3 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Remarks:

respiration rate

Effect concentrations 2

Duration:

3 h

Dose descriptor:

IC0

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

inhibition of total respiration

Remarks:

respiration rate

Any other information on results incl. tables

Respiration data

Test vessel	pH after 3 h	O2-consumption (mg O2 min/L)	% of control
Blank 1	8.1	1.28	-
Blank 2	8.1	1.46	-
100 mg/L	8.0	1.42	100.0
10 mg/L	8.2	1.28	93.4