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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This animal study is not performed according to GLP, but the test parameters are well documented and scientifically acceptable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Hungarian authority requirements: MÉM Agrokémiai Főosztály
Principles of method if other than guideline:
Methods in Toxicology ( 19709 Balazs, T. Blackwell Scientific Publ. Oxf.-Edinburgh, 49-81.
Zbinden, G. and Flury-Roversi, M. (1981) Archives of Toxicology , 47, 77-99.
Finney, D.J (1952) Probit Analysis. Cambridge, Univ. Press
GLP compliance:
no
Test type:
other: Hungarian authority requirements: MÉM Agrokémiai Főosztály

Test material

Constituent 1
Chemical structure
Reference substance name:
EPTC
EC Number:
212-073-8
EC Name:
EPTC
Cas Number:
759-94-4
Molecular formula:
C9H19NOS
IUPAC Name:
N,N-dipropyl(ethylsulfanyl)formamide
Test material form:
not specified

Test animals

Species:
rat
Strain:
other: PVG/C, SPF
Sex:
male

Administration / exposure

Route of administration:
other: intraperitonealis szabad hasüregbe történő bejuttatás
Vehicle:
not specified
Doses:
Dózis ( mg / kg): 0, 475, 570, 665, 760, 808, 855
No. of animals per sex per dose:
4 male / dose
Control animals:
yes

Results and discussion

Preliminary study:
Doses: 23.7, 47.5, 71.2, 95.0, 118.8, 142.5, 237.5, 475.0, 950.0 -died a female, 1900.0 -died both , 3800.0 - died both
2 animals ( male and female)/doses
ALD = 950 mg/ bw-kg
Acute toxicity study is needed.
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 760 mg/kg bw
Based on:
not specified
95% CL:
ca. 656 - 874
Mortality:
At 0 mg/kg dose 0 died out of 4 rats.
At 475 mg/kg dose 1 died out of 4
At 570 mg/kg dose 2 died out of 4
At 665 mg/kg dose 2 died out of 4
At 760mg/kg dose 3 died out of 4
At 808 mg/kg dose 4 died out of 4
At 855 mg/kg dose 4 died out of 4
Clinical signs:
other: Status: Néhány óra alatt kialakuló toxikus tünetek követik a parenteralis bevitelt. Rendkívüli levertség, tónustalanság, időnkénti görcsös rángások jellemzőek. Az elhullások 12-24 órán belül következnek be. A túlélő állatok állapota rendkívül lassan rend
Gross pathology:
Bonclelet: Az akut stádiumban elhullott állatok mellűri statusa negatív, az abdominalis status az irritalt peritoneum jellegzetes képét mutatja. Belövelt abdominalis zsigerek, erezett, lobos peritoneum, kismértékben megnagyobbodott máj. A túlélő állatokban az irritáció következtében peritonitis alakul ki, amely a szokásos képpel, - ascites, összenövések- járt.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 760 mg/ bw-kg this is acut toxicity category IV (between the cat IV limit 300-2000) Acut tox Category 4 H302
Executive summary:

According to this study the LD50 of EPTC is 760 mg/bw-kg. ( rat, male) Acut tox Category 4 H302