Registration Dossier
Registration Dossier
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EC number: 204-436-4 | CAS number: 120-93-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-imidazolidone
- EC Number:
- 204-436-4
- EC Name:
- 2-imidazolidone
- Cas Number:
- 120-93-4
- Molecular formula:
- C3H6N2O
- IUPAC Name:
- 2-imidazolidone
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- 1 and 10% in aqueous solution
- Doses:
- 20, 79, 316, 1260 and 5010 mg/kg bw
- No. of animals per sex per dose:
- high dose: 10 animals
lower doses: 1 animal - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: after 1 hour, 24 hours, 48 hours, 3 days and 7 days.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- Blood congestion in the liver and spleen in 4 animals at the high dose.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute oral toxicity study in rats, the LD50 value was greater than 5010 mg/kg bw.
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